FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078631728> ?p ?o ?g. }

• W2078631728 endingPage "558" @default.
• W2078631728 startingPage "550" @default.
• W2078631728 abstract "Hypertension represents a major risk factor for cardiovascular diseases. We have developed a novel transgenic mouse model by overexpressing the cDNA of human profilin1 in the blood vessels of transgenic mice, which led to vascular hypertrophy and hypertension. We assessed the effects of losartan, amlodipine, or atenolol on vascular hypertrophy-associated hypertension, by treating the profilin1 transgenic mice for 4 weeks. Our myograph results showed improvement in the contraction response toward phenylephrine and in the relaxation response toward acetylcholine and sodium nitrite in losartan- and amlodipine-treated profilin1 mice. Western blot analyses using mesenteric arteries of losartan- and amlodipine-treated profilin1 mice showed significant decreases in their signaling, respectively, as follows: the expression of α1 integrin (104% and 93%) and β1 integrin (116% and 109%); p-ERK1/2 (149% and 130%) and p-JNK (171% and 137%); the phospho-myosin light chain 20 (117% and 150%); and the ROCKII expression (125% and 180%). Conversely, there were significant increases in the endothelial nitric oxide synthase expression (82% and 80%) and activation (p-endothelial nitric oxide synthase) (78% and 76%). On the other hand, atenolol-treated profilin1 mice showed no significant change in all measured parameters. In conclusion, the profilin1 gene may represent a new therapeutic target in the treatment of vascular hypertrophy-associated hypertension." @default.
• W2078631728 created "2016-06-24" @default.
• W2078631728 creator A5012245576 @default.
• W2078631728 creator A5039663877 @default.
• W2078631728 creator A5058440204 @default.
• W2078631728 creator A5064807660 @default.
• W2078631728 creator A5075294219 @default.
• W2078631728 creator A5086378262 @default.
• W2078631728 date "2011-05-01" @default.
• W2078631728 modified "2023-09-27" @default.
• W2078631728 title "The Effect of Selective Antihypertensive Drugs on the Vascular Remodeling-associated Hypertension: Insights From a Profilin1 Transgenic Mouse Model" @default.
• W2078631728 cites W1582771675 @default.
• W2078631728 cites W1592294264 @default.
• W2078631728 cites W1982617847 @default.
• W2078631728 cites W1986000579 @default.
• W2078631728 cites W1989728414 @default.
• W2078631728 cites W1990932442 @default.
• W2078631728 cites W1994648099 @default.
• W2078631728 cites W1994811935 @default.
• W2078631728 cites W1997158886 @default.
• W2078631728 cites W2005705777 @default.
• W2078631728 cites W2011379117 @default.
• W2078631728 cites W2017023029 @default.
• W2078631728 cites W2032295238 @default.
• W2078631728 cites W2038309331 @default.
• W2078631728 cites W2041037406 @default.
• W2078631728 cites W2046845297 @default.
• W2078631728 cites W2051033301 @default.
• W2078631728 cites W2061530710 @default.
• W2078631728 cites W2069924575 @default.
• W2078631728 cites W2071143898 @default.
• W2078631728 cites W2072568001 @default.
• W2078631728 cites W2077123176 @default.
• W2078631728 cites W2079891784 @default.
• W2078631728 cites W2081383439 @default.
• W2078631728 cites W2082291507 @default.
• W2078631728 cites W2085494449 @default.
• W2078631728 cites W2097792029 @default.
• W2078631728 cites W2098661052 @default.
• W2078631728 cites W2102052376 @default.
• W2078631728 cites W2114630275 @default.
• W2078631728 cites W2121711919 @default.
• W2078631728 cites W2122595781 @default.
• W2078631728 cites W2125678486 @default.
• W2078631728 cites W2131033837 @default.
• W2078631728 cites W2131624158 @default.
• W2078631728 cites W2139221736 @default.
• W2078631728 cites W2146172538 @default.
• W2078631728 cites W2150462388 @default.
• W2078631728 cites W2157057477 @default.
• W2078631728 cites W2161467739 @default.
• W2078631728 cites W2165971798 @default.
• W2078631728 cites W2314840537 @default.
• W2078631728 cites W2930561235 @default.
• W2078631728 doi "https://doi.org/10.1097/fjc.0b013e318212b1c2" @default.
• W2078631728 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21326111" @default.
• W2078631728 hasPublicationYear "2011" @default.
• W2078631728 type Work @default.
• W2078631728 sameAs 2078631728 @default.
• W2078631728 citedByCount "11" @default.
• W2078631728 countsByYear W20786317282012 @default.
• W2078631728 countsByYear W20786317282013 @default.
• W2078631728 countsByYear W20786317282014 @default.
• W2078631728 countsByYear W20786317282017 @default.
• W2078631728 countsByYear W20786317282018 @default.
• W2078631728 countsByYear W20786317282021 @default.
• W2078631728 crossrefType "journal-article" @default.
• W2078631728 hasAuthorship W2078631728A5012245576 @default.
• W2078631728 hasAuthorship W2078631728A5039663877 @default.
• W2078631728 hasAuthorship W2078631728A5058440204 @default.
• W2078631728 hasAuthorship W2078631728A5064807660 @default.
• W2078631728 hasAuthorship W2078631728A5075294219 @default.
• W2078631728 hasAuthorship W2078631728A5086378262 @default.
• W2078631728 hasConcept C126322002 @default.
• W2078631728 hasConcept C134018914 @default.
• W2078631728 hasConcept C167414201 @default.
• W2078631728 hasConcept C185592680 @default.
• W2078631728 hasConcept C2776525901 @default.
• W2078631728 hasConcept C2776820930 @default.
• W2078631728 hasConcept C2777622882 @default.
• W2078631728 hasConcept C2777952589 @default.
• W2078631728 hasConcept C2779646130 @default.
• W2078631728 hasConcept C2779941686 @default.
• W2078631728 hasConcept C2780288358 @default.
• W2078631728 hasConcept C2780771799 @default.
• W2078631728 hasConcept C2908929049 @default.
• W2078631728 hasConcept C519581460 @default.
• W2078631728 hasConcept C71924100 @default.
• W2078631728 hasConcept C84393581 @default.
• W2078631728 hasConcept C98274493 @default.
• W2078631728 hasConceptScore W2078631728C126322002 @default.
• W2078631728 hasConceptScore W2078631728C134018914 @default.
• W2078631728 hasConceptScore W2078631728C167414201 @default.
• W2078631728 hasConceptScore W2078631728C185592680 @default.
• W2078631728 hasConceptScore W2078631728C2776525901 @default.
• W2078631728 hasConceptScore W2078631728C2776820930 @default.
• W2078631728 hasConceptScore W2078631728C2777622882 @default.
• W2078631728 hasConceptScore W2078631728C2777952589 @default.

• next