Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078632822> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2078632822 endingPage "771" @default.
- W2078632822 startingPage "751" @default.
- W2078632822 abstract "A choline acetyltransferase (ChA) inhibitor with an optimum combination of properties of potency, stability and membrane permeability is required to study several functional aspects of acetylcholine in nervous and non-nervous tissues. Therefore, 2-(alpha-naphthoyl)ethyltrimethylammonium iodide (alpha-NETA), 2-(beta-naphthoyl)ethyltrimethylammonium iodide (beta-NETA), 2-(9'-anthroyl)ethyltrimethylammonium iodide (9'-AETA) and their corresponding tertiary dimethylamine hydrochloride analogs (alpha-NEDA, beta-NEDA, 9'-AEDA) were synthesized and tested for their ChA inhibitory activities. The quaternary ammonium compounds were more potent inhibitors (150 in microM: alpha-NETA, 9; beta-NETA, 76; 9'-AETA, 32) than the corresponding tertiary compounds (150 in microM: alpha-NEDA, 63; beta-NEDA, 1400; 9'-AEDA, 77). The alpha-naphthyl moiety was preferable to the beta-naphthyl- or 9'-anthryl moieties for alignment with the enzyme for inhibition. alpha-NETA and alpha-NEDA exhibited adequate ChA inhibitory potencies for further pharmacological studies and localization of membrane bound ChA. They exhibited fluorescent characteristics of the alpha-naphthyl moiety. Their ChA inhibition was not reversible by dialysis. They were considerably more potent for inhibiting ChA than cholinesterases and carnitine acetyltransferase." @default.
- W2078632822 created "2016-06-24" @default.
- W2078632822 creator A5037546575 @default.
- W2078632822 creator A5055972374 @default.
- W2078632822 creator A5057120231 @default.
- W2078632822 creator A5075745480 @default.
- W2078632822 creator A5090974608 @default.
- W2078632822 date "1988-09-01" @default.
- W2078632822 modified "2023-09-27" @default.
- W2078632822 title "Relationships between chemical structure and inhibition of choline acetyltransferase by 2-(α-naphthoyl)ethyltrimethylammonium and related compounds" @default.
- W2078632822 cites W1970014969 @default.
- W2078632822 cites W1971048984 @default.
- W2078632822 cites W1975710420 @default.
- W2078632822 cites W1982873198 @default.
- W2078632822 cites W1992533922 @default.
- W2078632822 cites W1999527619 @default.
- W2078632822 cites W2000322970 @default.
- W2078632822 cites W2024760927 @default.
- W2078632822 cites W2038924889 @default.
- W2078632822 cites W2044562660 @default.
- W2078632822 cites W2046849744 @default.
- W2078632822 cites W2062978587 @default.
- W2078632822 cites W2068711231 @default.
- W2078632822 cites W2083253619 @default.
- W2078632822 cites W2088025276 @default.
- W2078632822 cites W2092801755 @default.
- W2078632822 cites W2112374243 @default.
- W2078632822 cites W2136506108 @default.
- W2078632822 cites W2256900562 @default.
- W2078632822 doi "https://doi.org/10.1016/s0031-6989(88)80715-x" @default.
- W2078632822 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3174803" @default.
- W2078632822 hasPublicationYear "1988" @default.
- W2078632822 type Work @default.
- W2078632822 sameAs 2078632822 @default.
- W2078632822 citedByCount "10" @default.
- W2078632822 countsByYear W20786328222014 @default.
- W2078632822 countsByYear W20786328222019 @default.
- W2078632822 countsByYear W20786328222021 @default.
- W2078632822 countsByYear W20786328222022 @default.
- W2078632822 crossrefType "journal-article" @default.
- W2078632822 hasAuthorship W2078632822A5037546575 @default.
- W2078632822 hasAuthorship W2078632822A5055972374 @default.
- W2078632822 hasAuthorship W2078632822A5057120231 @default.
- W2078632822 hasAuthorship W2078632822A5075745480 @default.
- W2078632822 hasAuthorship W2078632822A5090974608 @default.
- W2078632822 hasConcept C155647269 @default.
- W2078632822 hasConcept C159110408 @default.
- W2078632822 hasConcept C178790620 @default.
- W2078632822 hasConcept C185592680 @default.
- W2078632822 hasConcept C2775944032 @default.
- W2078632822 hasConcept C2776568683 @default.
- W2078632822 hasConcept C2778870691 @default.
- W2078632822 hasConcept C2781123555 @default.
- W2078632822 hasConcept C49453240 @default.
- W2078632822 hasConcept C55493867 @default.
- W2078632822 hasConcept C64943373 @default.
- W2078632822 hasConcept C71240020 @default.
- W2078632822 hasConcept C71924100 @default.
- W2078632822 hasConceptScore W2078632822C155647269 @default.
- W2078632822 hasConceptScore W2078632822C159110408 @default.
- W2078632822 hasConceptScore W2078632822C178790620 @default.
- W2078632822 hasConceptScore W2078632822C185592680 @default.
- W2078632822 hasConceptScore W2078632822C2775944032 @default.
- W2078632822 hasConceptScore W2078632822C2776568683 @default.
- W2078632822 hasConceptScore W2078632822C2778870691 @default.
- W2078632822 hasConceptScore W2078632822C2781123555 @default.
- W2078632822 hasConceptScore W2078632822C49453240 @default.
- W2078632822 hasConceptScore W2078632822C55493867 @default.
- W2078632822 hasConceptScore W2078632822C64943373 @default.
- W2078632822 hasConceptScore W2078632822C71240020 @default.
- W2078632822 hasConceptScore W2078632822C71924100 @default.
- W2078632822 hasIssue "9" @default.
- W2078632822 hasLocation W20786328221 @default.
- W2078632822 hasLocation W20786328222 @default.
- W2078632822 hasOpenAccess W2078632822 @default.
- W2078632822 hasPrimaryLocation W20786328221 @default.
- W2078632822 hasRelatedWork W2045060966 @default.
- W2078632822 hasRelatedWork W2069211232 @default.
- W2078632822 hasRelatedWork W2088374148 @default.
- W2078632822 hasRelatedWork W2299102347 @default.
- W2078632822 hasRelatedWork W2816948243 @default.
- W2078632822 hasRelatedWork W2951586403 @default.
- W2078632822 hasRelatedWork W2951655361 @default.
- W2078632822 hasRelatedWork W4206217756 @default.
- W2078632822 hasRelatedWork W73525949 @default.
- W2078632822 hasRelatedWork W2023570923 @default.
- W2078632822 hasVolume "20" @default.
- W2078632822 isParatext "false" @default.
- W2078632822 isRetracted "false" @default.
- W2078632822 magId "2078632822" @default.
- W2078632822 workType "article" @default.