FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078633164> ?p ?o ?g. }

• W2078633164 endingPage "777" @default.
• W2078633164 startingPage "767" @default.
• W2078633164 abstract "The anatomical distributions and affinity states of dopamine D1 and D2 receptors were compared in the rat central nervous system using quantitative autoradiography. [3H]SCH23390 and [3H]spiperone (in the presence of 100 nM mianserin) were used to label the D1, and D2 receptors, respectively. The densities of D1 and D2 receptors displayed a positive correlation among 21 brain regions (Pearson correlation coefficient, r = 0.80, P < 0.001). The affinity states for the D1 and D2 receptors were found to be quite different from each other, and different from the results obtained by others using homogenate preparations. Both the D1 and D2 receptors were best modeled using a two-state model. In the absence of exogenous guanine nucleotides and using the nonselective agonist dopamine as the competitor, the D1 receptor was primarily in a low affinity agonist state (RH = 21 ± 6%), whereas the D2 receptor was primarily in the high affinity agonist state (RH = 77 ± 3%). In the presence of 10 μM guanylyl-imidodiphosphate orguanosine-5'-O-(2-thiophosphate) both the D1 and the D2 receptor were completely in a low affinity agonist state (RL = 100%). These affinity states were found both in the nucleus accumbens and olfactory tubercle using dopamine as the competitor and in the striatum using selective D1 or D2 agonists as competitors. Receptor occupancy of the D2 receptor with either an agonist or antagonist did not alter the affinity states of the D1 receptor, and conversely, receptor occupancy of the D1 receptor did not alter the affinity states of the D2 receptor. The correlation between densities of D1 and D2 receptors provides an anatomical framework for evaluating behavioral and electrophysiological evidence of an interaction between the two dopamine receptor subtypes. This interaction does not appear to be due to a sharing or coupling of G-proteins in such a way that binding to one dopamine receptor subtype alters the affinity state of the other receptor subtype. The differences between dopamine receptor distributions described by labeled agonists and antagonists may be due in part to differences in their affinity states. The low proportion of high affinity state D1 receptors may explain some of the difficulties in assigning specific behavioral roles to the D1 receptor." @default.
• W2078633164 created "2016-06-24" @default.
• W2078633164 creator A5019611038 @default.
• W2078633164 creator A5044891578 @default.
• W2078633164 creator A5057416374 @default.
• W2078633164 date "1989-01-01" @default.
• W2078633164 modified "2023-10-17" @default.
• W2078633164 title "Anatomical and affinity state comparisons between dopamine D1 and D2 receptors in the rat central nervous system" @default.
• W2078633164 cites W1502396858 @default.
• W2078633164 cites W1502799818 @default.
• W2078633164 cites W1503918021 @default.
• W2078633164 cites W1510793262 @default.
• W2078633164 cites W1598210821 @default.
• W2078633164 cites W1637093671 @default.
• W2078633164 cites W1829440589 @default.
• W2078633164 cites W1884206649 @default.
• W2078633164 cites W1912564681 @default.
• W2078633164 cites W1917378969 @default.
• W2078633164 cites W1966176551 @default.
• W2078633164 cites W1966308411 @default.
• W2078633164 cites W1973162641 @default.
• W2078633164 cites W1976045951 @default.
• W2078633164 cites W1976553411 @default.
• W2078633164 cites W1981988180 @default.
• W2078633164 cites W1985576201 @default.
• W2078633164 cites W1985695713 @default.
• W2078633164 cites W1987563992 @default.
• W2078633164 cites W1994429247 @default.
• W2078633164 cites W1998529563 @default.
• W2078633164 cites W2002175275 @default.
• W2078633164 cites W2004094484 @default.
• W2078633164 cites W2004884698 @default.
• W2078633164 cites W2012126965 @default.
• W2078633164 cites W2022649017 @default.
• W2078633164 cites W2023082044 @default.
• W2078633164 cites W2025564011 @default.
• W2078633164 cites W2025961985 @default.
• W2078633164 cites W2026077845 @default.
• W2078633164 cites W2026339353 @default.
• W2078633164 cites W2030683825 @default.
• W2078633164 cites W2030905853 @default.
• W2078633164 cites W2032456750 @default.
• W2078633164 cites W2034113474 @default.
• W2078633164 cites W2035398018 @default.
• W2078633164 cites W2036847153 @default.
• W2078633164 cites W2038054494 @default.
• W2078633164 cites W2043393596 @default.
• W2078633164 cites W2050580902 @default.
• W2078633164 cites W2051414078 @default.
• W2078633164 cites W2053248981 @default.
• W2078633164 cites W2056700078 @default.
• W2078633164 cites W2057788173 @default.
• W2078633164 cites W2066991732 @default.
• W2078633164 cites W2069062297 @default.
• W2078633164 cites W2069639335 @default.
• W2078633164 cites W2069844118 @default.
• W2078633164 cites W2077108130 @default.
• W2078633164 cites W2081190259 @default.
• W2078633164 cites W2081385433 @default.
• W2078633164 cites W2088541353 @default.
• W2078633164 cites W2088878456 @default.
• W2078633164 cites W2089154427 @default.
• W2078633164 cites W2092252880 @default.
• W2078633164 cites W2114722814 @default.
• W2078633164 cites W2127087784 @default.
• W2078633164 cites W2147347610 @default.
• W2078633164 cites W2150807108 @default.
• W2078633164 doi "https://doi.org/10.1016/0306-4522(89)90168-1" @default.
• W2078633164 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2528080" @default.
• W2078633164 hasPublicationYear "1989" @default.
• W2078633164 type Work @default.
• W2078633164 sameAs 2078633164 @default.
• W2078633164 citedByCount "408" @default.
• W2078633164 countsByYear W20786331642012 @default.
• W2078633164 countsByYear W20786331642013 @default.
• W2078633164 countsByYear W20786331642014 @default.
• W2078633164 countsByYear W20786331642015 @default.
• W2078633164 countsByYear W20786331642016 @default.
• W2078633164 countsByYear W20786331642017 @default.
• W2078633164 countsByYear W20786331642018 @default.
• W2078633164 countsByYear W20786331642019 @default.
• W2078633164 countsByYear W20786331642020 @default.
• W2078633164 countsByYear W20786331642021 @default.
• W2078633164 countsByYear W20786331642022 @default.
• W2078633164 countsByYear W20786331642023 @default.
• W2078633164 crossrefType "journal-article" @default.
• W2078633164 hasAuthorship W2078633164A5019611038 @default.
• W2078633164 hasAuthorship W2078633164A5044891578 @default.
• W2078633164 hasAuthorship W2078633164A5057416374 @default.
• W2078633164 hasBestOaLocation W20786331642 @default.
• W2078633164 hasConcept C120069818 @default.
• W2078633164 hasConcept C120750228 @default.
• W2078633164 hasConcept C126322002 @default.
• W2078633164 hasConcept C134018914 @default.
• W2078633164 hasConcept C14200731 @default.
• W2078633164 hasConcept C160262196 @default.
• W2078633164 hasConcept C170493617 @default.
• W2078633164 hasConcept C185592680 @default.

• next