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• W2078635213 abstract "RNA silencing comprises a set of sequence-specific RNA degradation pathways that occur in a wide range of eukaryotes, including animals, fungi and plants. A hallmark of RNA silencing is the presence of small interfering RNA molecules (siRNAs). The siRNAs are generated by cleavage of larger double-stranded RNAs (dsRNAs) and provide the sequence specificity for degradation of cognate RNA molecules. In plants, RNA silencing plays a key role in developmental processes and in control of virus replication. It has been shown that many plant viruses encode proteins, denoted RNA silencing suppressors, that interfere with this antiviral response. Although RNA silencing has been shown to occur in vertebrates, no relationship with inhibition of virus replication has been demonstrated to date. Here we show that the NS1 protein of human influenza A virus has an RNA silencing suppression activity in plants, similar to established RNA silencing suppressor proteins of plant viruses. In addition, NS1 was shown to be capable of binding siRNAs. The data presented here fit with a potential role for NS1 in counteracting innate antiviral responses in vertebrates by sequestering siRNAs." @default.
• W2078635213 created "2016-06-24" @default.
• W2078635213 creator A5054588923 @default.
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• W2078635213 date "2004-04-01" @default.
• W2078635213 modified "2023-10-13" @default.
• W2078635213 title "The influenza A virus NS1 protein binds small interfering RNAs and suppresses RNA silencing in plants" @default.
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• W2078635213 doi "https://doi.org/10.1099/vir.0.19734-0" @default.
• W2078635213 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15039540" @default.
• W2078635213 hasPublicationYear "2004" @default.
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