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- W2078637057 abstract "Spectroscopic studies of four amphotericin B (AmB) lipid preparations—small negatively charged unilamellar vesicles “AmBisome”, positively charged oligolamellar liposomes “Ampholiposomes”, AmB Lipid Complex “L-AmpB33”—and AmB association with γ cyclodextrin demonstrated that the composition of drug delivery system directly influences AmB organization. The aggregation state and release in external medium of AmB was monitored by circular dichroism and UV-visible absorption. AmB short-term activity against Candida albicans (K+ leakage) was found to be correlated with the amount of free AmB released from lipid preparations. These data seem to indicate that lipid composition influences anti-Candida albicans activity, by modulation of AmB binding to lipids." @default.
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- W2078637057 date "1997-01-01" @default.
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- W2078637057 title "Release of Amphotericin B from Delivery Systems and its Action Against Fungal and Mammalian Cells" @default.
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- W2078637057 doi "https://doi.org/10.3109/10611869708995847" @default.
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