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- W2078641185 abstract "Abstract Osteonectin function in bone was investigated by infrared analysis of bones from osteonectin‐null (KO) and wildtype mice (four each at 11, 17, and 36 weeks). An increase in mineral content and crystallinity in newly formed KO bone and collagen maturity at all sites was found using FTIR microspectroscopy and imaging; consistent with osteonectin's postulated role in regulating bone formation and remodeling. Mineral and matrix properties of tibias of osteonectin‐null mice and their age‐ and background‐matched wildtype controls were compared using Fourier‐transform infrared microspectroscopy (FTIRM) and infrared imaging (FTIRI) at 10‐ and 7‐mm spatial resolution, respectively. The bones came from animals that were 11, 17, and 36 weeks of age. Individual FTIRM spectra were acquired from 20 × 20 μm areas, whereas 4096 simultaneous FTIRI spectra were acquired from 400 × 400 μm areas. The FTIRM data for mineral‐to‐matrix, mineral crystallinity, and collagen maturity were highly correlated with the FTIRI data in similar regions. In general, the osteonectin‐null mice bones had higher mineral contents and greater crystallinity (crystal size and perfection) than the age‐matched wildtype controls. Specifically, the mineral content of the newly forming periosteal bone was increased in the osteonectin‐null mice; the crystallinity of the cortical bone was decreased in all but the oldest animals, relative to the wildtype. The most significant finding, however, was increased collagen maturity in both the cortical and trabecular bone of the osteonectin‐null mice. These spectroscopic data are consistent with a mechanism of decreased bone formation and remodeling." @default.
- W2078641185 created "2016-06-24" @default.
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- W2078641185 date "2003-06-01" @default.
- W2078641185 modified "2023-10-15" @default.
- W2078641185 title "Infrared Analysis of the Mineral and Matrix in Bones of Osteonectin-Null Mice and Their Wildtype Controls" @default.
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- W2078641185 doi "https://doi.org/10.1359/jbmr.2003.18.6.1005" @default.
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