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- W2078642122 abstract "Abstract In this study, we developed a novel bioeliminable amphiphilic glycopoly(pseudo amino acid), which was synthesized by the condensation polymerization of N-benzyloxycarbonyl-4-hydroxyl- l -proline (NZHpr) followed by the coupling of an alkynyl-functional sugar derivative to the azido-end group, P(NZHpr)n. The glycosylated P(NZHpr)n polymers formed micelles in the aqueous phase. Selective lectin binding experiments confirmed that the glycosylated P(NZHpr)n can be used in biorecognition applications. The DOX-loaded micelles facilitated improved uptake of DOX by HeLa cells within 2 h and were primarily retained in the cytoplasm, whereas free DOX tended to accumulate in the nuclei. The DOX-loaded glucosylated P(NZHpr)n micelles exhibited a substantially lower cytotoxicity compared to free DOX." @default.
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- W2078642122 date "2012-09-01" @default.
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- W2078642122 title "Synthesis of glycopoly(pseudo amino acid)s and their interaction with lectins" @default.
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- W2078642122 doi "https://doi.org/10.1016/j.reactfunctpolym.2012.06.003" @default.
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