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- W2078644815 abstract "Abstract Protein kinase C (PKC) inhibitors are under investigation as potential anti-arthritic drugs. Attempts to resolve a lead compound into its respective enantiomers were made using normal chiral phase methodologies, e.g., Chiralcel OD, OG, OJ using isopropanol-hexane mixtures. Although good retention was achieved on some chiral columns, no separation was seen. Silica-based cellulose tris-3,5-dimethylphenylcarbamate, Chiralcel OD, has been used previously to successfully resolve various drugs by reversed-phase HPLC using aqueous buffer-acetonitrile eluting systems. This work investigates the direct chiral resolution of a range of PKC inhibitor racemates by reversed-phase chiral HPLC on Chiralcel OD using acetonitrile-phosphate buffer mixtures. The effect on the separation was studied with variables such as acetonitrile concentration, flow-rate, buffer pH and column temperature. The effect on chromatography at sub-ambient temperature is discussed and examples are given where enhancement on resolution was achieved. In some cases baseline separation was obtained allowing determination of enantiomeric excess down to 0.1% level. Although an increase in band broadening was observed as the temperature was reduced it did not reach an unacceptable level, even at 0°C." @default.
- W2078644815 created "2016-06-24" @default.
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- W2078644815 date "1995-04-01" @default.
- W2078644815 modified "2023-09-26" @default.
- W2078644815 title "Chiral resolution of protein kinase C inhibitors by reversed-phase high-performance liquid chromatography on cellulose tris-3,5-dimethylphenylcarbamate" @default.
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- W2078644815 doi "https://doi.org/10.1016/0021-9673(94)00748-x" @default.
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