Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078646711> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2078646711 endingPage "50" @default.
- W2078646711 startingPage "45" @default.
- W2078646711 abstract "In the dog, the emetic ED50 for sodium salicylate was 256 ± 113 mg/kg for the intravenous route with a mean latency of 10.4 ± 3.96 min, and for the oral route 228 ± 68 mg/kg with a mean latency of 18.2 ± 2.63 min. Values are means with standard errors. Ablation of the emetic chemoreceptor trigger-zone gave complete protection against the emetic action of 300 mg of sodium salicylate intravenously but only partial protection against the emetic action of the same dose of sodium salicylate orally. Either the intravenous salicylate acted on the trigger-zone or ablation of the trigger-zone interfered with afferent nerves from peripheral receptors responding to intravenous salicylate and which were different from the receptors responding to oral salicylate. After supradiaphragmatic vagotomy, there was equal protection against intravenous and oral salicylate. Two explanations can be advanced. First, the receptors responding to intravenous and those responding to oral salicylate have a common path in the vagus nerves; or second, afferent fibres in the vagus nerve normally maintain the vomiting centre in a reactive state. When these fibres are cut any other afferent fibres become less effective in evoking vomiting. Spinal transection gave partial and spinal transection with vagotomy gave complete protection. It is concluded that further work is necessary to decide which of the two explanations obtained." @default.
- W2078646711 created "2016-06-24" @default.
- W2078646711 creator A5036394955 @default.
- W2078646711 creator A5039204604 @default.
- W2078646711 creator A5054221588 @default.
- W2078646711 date "1963-08-01" @default.
- W2078646711 modified "2023-09-26" @default.
- W2078646711 title "THE MECHANISM OF THE EMETIC ACTION OF SODIUM SALICYLATE" @default.
- W2078646711 cites W1504814230 @default.
- W2078646711 cites W2003723149 @default.
- W2078646711 cites W2016989253 @default.
- W2078646711 cites W2032564860 @default.
- W2078646711 cites W2131882912 @default.
- W2078646711 cites W2410101111 @default.
- W2078646711 cites W2414225122 @default.
- W2078646711 doi "https://doi.org/10.1111/j.1476-5381.1963.tb01500.x" @default.
- W2078646711 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1703861" @default.
- W2078646711 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14066150" @default.
- W2078646711 hasPublicationYear "1963" @default.
- W2078646711 type Work @default.
- W2078646711 sameAs 2078646711 @default.
- W2078646711 citedByCount "6" @default.
- W2078646711 countsByYear W20786467112018 @default.
- W2078646711 crossrefType "journal-article" @default.
- W2078646711 hasAuthorship W2078646711A5036394955 @default.
- W2078646711 hasAuthorship W2078646711A5039204604 @default.
- W2078646711 hasAuthorship W2078646711A5054221588 @default.
- W2078646711 hasBestOaLocation W20786467111 @default.
- W2078646711 hasConcept C126322002 @default.
- W2078646711 hasConcept C185592680 @default.
- W2078646711 hasConcept C24998067 @default.
- W2078646711 hasConcept C2778720886 @default.
- W2078646711 hasConcept C2779134981 @default.
- W2078646711 hasConcept C2780852908 @default.
- W2078646711 hasConcept C2781404750 @default.
- W2078646711 hasConcept C42219234 @default.
- W2078646711 hasConcept C71924100 @default.
- W2078646711 hasConcept C98274493 @default.
- W2078646711 hasConceptScore W2078646711C126322002 @default.
- W2078646711 hasConceptScore W2078646711C185592680 @default.
- W2078646711 hasConceptScore W2078646711C24998067 @default.
- W2078646711 hasConceptScore W2078646711C2778720886 @default.
- W2078646711 hasConceptScore W2078646711C2779134981 @default.
- W2078646711 hasConceptScore W2078646711C2780852908 @default.
- W2078646711 hasConceptScore W2078646711C2781404750 @default.
- W2078646711 hasConceptScore W2078646711C42219234 @default.
- W2078646711 hasConceptScore W2078646711C71924100 @default.
- W2078646711 hasConceptScore W2078646711C98274493 @default.
- W2078646711 hasIssue "1" @default.
- W2078646711 hasLocation W20786467111 @default.
- W2078646711 hasLocation W20786467112 @default.
- W2078646711 hasLocation W20786467113 @default.
- W2078646711 hasLocation W20786467114 @default.
- W2078646711 hasOpenAccess W2078646711 @default.
- W2078646711 hasPrimaryLocation W20786467111 @default.
- W2078646711 hasRelatedWork W1972520018 @default.
- W2078646711 hasRelatedWork W1981925462 @default.
- W2078646711 hasRelatedWork W2015057576 @default.
- W2078646711 hasRelatedWork W2056665045 @default.
- W2078646711 hasRelatedWork W2325214449 @default.
- W2078646711 hasRelatedWork W2377696384 @default.
- W2078646711 hasRelatedWork W2410189062 @default.
- W2078646711 hasRelatedWork W2410518982 @default.
- W2078646711 hasRelatedWork W2481246488 @default.
- W2078646711 hasRelatedWork W2016375685 @default.
- W2078646711 hasVolume "21" @default.
- W2078646711 isParatext "false" @default.
- W2078646711 isRetracted "false" @default.
- W2078646711 magId "2078646711" @default.
- W2078646711 workType "article" @default.