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- W2078647191 abstract "Abstract Vinblastine (VLB) was incubated in bile from a dog at 37 °C for 72 h. The reaction mixture was extracted with methylene chloride and the extract gave four major peaks (A, B, C, and D) with retention times of 4.0, 6.5, 9.8, and 28.0 min, respectively, in an HPLC system (μBondapak C18 column; solvent, 50% MeOH in 10 mM KH2PO4, pH 4.0; flow rate, 1.3 ml/min; detector, 254 nm). In the HPLC system, VLB corresponded with peak C and its spectral properties were identical to the parent compound. The UV, IR, and MS data of these peaks were as follows [UV (λmax); IR (cm−1); MS ( m z )]: peak A: 212, 252, 295 nm; 3363, 2922, 2850, 1734, 1611, 1455, 1373, 1235, 1036, 745; 769 (MH+); peak B: 210, 253, 282, 302 nm; 3421, 2922, 2850, 1734, 1452, 1369, 1040, 740; 809 (MH+); peak C: 214, 255, 280, 290 nm; 3468, 2919, 2851, 1742, 1461, 1373, 1041, 745; 811 (MH+); peak D: 208, 255, 288, 312 nm; 3570, 2919, 2850, 1739, 1464, 1383, 1036, 725; 825 (MH+). The following tentative structures for the products are proposed: peak A, 4-deacetylvinblastine; peak B, 3′,4′-anhydrovinblastine N-oxide; and peak D, 19′-oxovinblastine. The structure of peak A as 4-deacetylvinblastine was confirmed by chemical synthesis." @default.
- W2078647191 created "2016-06-24" @default.
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- W2078647191 date "1990-06-01" @default.
- W2078647191 modified "2023-09-26" @default.
- W2078647191 title "Characterization of the products of vinblastine dihydrogen sulfate formed after in vitro incubation in bile" @default.
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- W2078647191 doi "https://doi.org/10.1016/0026-265x(90)90135-r" @default.
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