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• W2078647277 abstract "GLI1 oncogene mediates the effects of the signalling molecule Sonic Hedgehog, involved in the control of differentiation and morphogenesis during embryonic development and postnatal life [ 1 Villavicencio E.H. Walterhouse D.O. Iannaccone P.M. The sonic hedgehog-patched-gli pathway in human development and disease. Am J Hum Genet. 2000; 67: 1047-1054 Abstract Full Text Full Text PDF PubMed Scopus (342) Google Scholar , 2 Ghali L. Wong S.T. Green J. Tidman N. Quinn A.G. Gli1 protein is expressed in basal cell carcinomas, outer root sheath keratinocytes and a subpopulation of mesenchymal cells in normal human skin. J Invest Dermatol. 1999; 113: 595-599 Crossref PubMed Scopus (85) Google Scholar ]. Methods to modulate GLI1 expression without knocking out the gene have not yet been devised. Since GLI1 is specifically expressed by basal cell carcinoma (BCC) [ 2 Ghali L. Wong S.T. Green J. Tidman N. Quinn A.G. Gli1 protein is expressed in basal cell carcinomas, outer root sheath keratinocytes and a subpopulation of mesenchymal cells in normal human skin. J Invest Dermatol. 1999; 113: 595-599 Crossref PubMed Scopus (85) Google Scholar , 3 Green J. Leigh I.M. Poulsom R. Quinn A.G. Basal cell carcinoma development is associated with induction of the expression of the transcription factor Gli-1. Br J Dermatol. 1998; 139: 911-915 Crossref PubMed Scopus (57) Google Scholar ], which expression is considered a diagnostic hallmark and a pathogenetically meaningful event [ [4] Hatta N. Hirano T. Kimura T. Hashimoto K. Mehregan D.R. Ansai S. et al. Molecular diagnosis of basal cell carcinoma and other basaloid cell neoplasms of the skin by the quantification of Gli1 transcript levels. J Cutan Pathol. 2005; 32: 131-136 Crossref PubMed Scopus (33) Google Scholar ], BCC cells might be valuable to investigate on GLI1 modulation and its consequences." @default.
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• W2078647277 date "2009-04-01" @default.
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• W2078647277 title "Tacrolimus causes reduced GLI1 expression and phenotypic changes in the TE 354.T basal cell carcinoma cell line" @default.
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• W2078647277 doi "https://doi.org/10.1016/j.jdermsci.2008.10.006" @default.
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