FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078647607> ?p ?o ?g. }

• W2078647607 endingPage "224" @default.
• W2078647607 startingPage "218" @default.
• W2078647607 abstract "Recent studies have demonstrated the insulin-like effects of oral vanadyl sulphate in the streptozotocin-diabetic rat, including the amelioration of hyperglycaemia and the prevention of diabetes-related cardiac and adipose tissue dysfunction. However, the possibility that vanadyl treatment, routinely initiated at 3 days after the induction of diabetes, had prevented the full cytotoxic destruction of the beta cell, and thus accounted for the apparent anti-diabetic properties of vanadyl was questioned. Hence in the present study, we examined the effectiveness of vanadyl sulphate as a glucose-lowering and anti-diabetic agent when administration was delayed from the time of induction of diabetes. Male Wistar rats were injected with a single intravenous dose of streptozotocin (55 mg/kg). Vanadyl sulphate was administered in the drinking water at a concentration of 0.75 mg/ml from 3, 10 and 17 days after the streptozotocin injection and treatment was then maintained for 5 months. Vanadyl intake was accompanied by lowered serum levels of triglyceride and cholesterol with no associated enhancement in circulating insulin. Vanadyl-treated diabetic animals showed improved glucose tolerance while insulin release in vivo was still markedly lower than in non-diabetic rats. Adipose tissue function, as expressed by basal and epinephrine-stimulated lipolysis in isolated adipose tissue, was also normalized in vanadyl-treated diabetic animals. These responses were all observed whether vanadyl treatment was initiated 3, 10 or 17 days after induction of diabetes. Finally, prolonged treatment with vanadyl sulphate (in this case up to 5 months) did not cause any apparent hepatic toxicity as assessed histologically. Diabetes-induced morphological changes in the kidney were also prevented by vanadyl treatment.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
• W2078647607 created "2016-06-24" @default.
• W2078647607 creator A5024308096 @default.
• W2078647607 creator A5047386793 @default.
• W2078647607 creator A5076497150 @default.
• W2078647607 creator A5086814411 @default.
• W2078647607 date "1993-03-01" @default.
• W2078647607 modified "2023-09-24" @default.
• W2078647607 title "Long-term effectiveness of oral vanadyl sulphate in streptozotocin-diabetic rats" @default.
• W2078647607 cites W1545221250 @default.
• W2078647607 cites W1547729980 @default.
• W2078647607 cites W1841821790 @default.
• W2078647607 cites W1965190424 @default.
• W2078647607 cites W198289730 @default.
• W2078647607 cites W1996266257 @default.
• W2078647607 cites W2000190808 @default.
• W2078647607 cites W2002223173 @default.
• W2078647607 cites W2002361702 @default.
• W2078647607 cites W2014657895 @default.
• W2078647607 cites W2017839874 @default.
• W2078647607 cites W2023489081 @default.
• W2078647607 cites W2033361896 @default.
• W2078647607 cites W2039707682 @default.
• W2078647607 cites W2056925433 @default.
• W2078647607 cites W2062749274 @default.
• W2078647607 cites W2063976715 @default.
• W2078647607 cites W2076111847 @default.
• W2078647607 cites W2087594620 @default.
• W2078647607 cites W2117942267 @default.
• W2078647607 cites W2118839146 @default.
• W2078647607 cites W2128201389 @default.
• W2078647607 cites W2226892380 @default.
• W2078647607 cites W2268729060 @default.
• W2078647607 cites W2403658647 @default.
• W2078647607 doi "https://doi.org/10.1007/bf00399953" @default.
• W2078647607 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8462769" @default.
• W2078647607 hasPublicationYear "1993" @default.
• W2078647607 type Work @default.
• W2078647607 sameAs 2078647607 @default.
• W2078647607 citedByCount "87" @default.
• W2078647607 countsByYear W20786476072012 @default.
• W2078647607 countsByYear W20786476072014 @default.
• W2078647607 countsByYear W20786476072016 @default.
• W2078647607 countsByYear W20786476072018 @default.
• W2078647607 countsByYear W20786476072019 @default.
• W2078647607 countsByYear W20786476072020 @default.
• W2078647607 countsByYear W20786476072021 @default.
• W2078647607 countsByYear W20786476072022 @default.
• W2078647607 countsByYear W20786476072023 @default.
• W2078647607 crossrefType "journal-article" @default.
• W2078647607 hasAuthorship W2078647607A5024308096 @default.
• W2078647607 hasAuthorship W2078647607A5047386793 @default.
• W2078647607 hasAuthorship W2078647607A5076497150 @default.
• W2078647607 hasAuthorship W2078647607A5086814411 @default.
• W2078647607 hasBestOaLocation W20786476071 @default.
• W2078647607 hasConcept C126322002 @default.
• W2078647607 hasConcept C134018914 @default.
• W2078647607 hasConcept C140985366 @default.
• W2078647607 hasConcept C171089720 @default.
• W2078647607 hasConcept C185592680 @default.
• W2078647607 hasConcept C2778024521 @default.
• W2078647607 hasConcept C2778163477 @default.
• W2078647607 hasConcept C2778913445 @default.
• W2078647607 hasConcept C2779280383 @default.
• W2078647607 hasConcept C2779306644 @default.
• W2078647607 hasConcept C29730261 @default.
• W2078647607 hasConcept C555293320 @default.
• W2078647607 hasConcept C71924100 @default.
• W2078647607 hasConceptScore W2078647607C126322002 @default.
• W2078647607 hasConceptScore W2078647607C134018914 @default.
• W2078647607 hasConceptScore W2078647607C140985366 @default.
• W2078647607 hasConceptScore W2078647607C171089720 @default.
• W2078647607 hasConceptScore W2078647607C185592680 @default.
• W2078647607 hasConceptScore W2078647607C2778024521 @default.
• W2078647607 hasConceptScore W2078647607C2778163477 @default.
• W2078647607 hasConceptScore W2078647607C2778913445 @default.
• W2078647607 hasConceptScore W2078647607C2779280383 @default.
• W2078647607 hasConceptScore W2078647607C2779306644 @default.
• W2078647607 hasConceptScore W2078647607C29730261 @default.
• W2078647607 hasConceptScore W2078647607C555293320 @default.
• W2078647607 hasConceptScore W2078647607C71924100 @default.
• W2078647607 hasIssue "3" @default.
• W2078647607 hasLocation W20786476071 @default.
• W2078647607 hasLocation W20786476072 @default.
• W2078647607 hasOpenAccess W2078647607 @default.
• W2078647607 hasPrimaryLocation W20786476071 @default.
• W2078647607 hasRelatedWork W1964688190 @default.
• W2078647607 hasRelatedWork W1976234278 @default.
• W2078647607 hasRelatedWork W1979277576 @default.
• W2078647607 hasRelatedWork W2006513370 @default.
• W2078647607 hasRelatedWork W2044897248 @default.
• W2078647607 hasRelatedWork W2048359366 @default.
• W2078647607 hasRelatedWork W2068408721 @default.
• W2078647607 hasRelatedWork W2081564223 @default.
• W2078647607 hasRelatedWork W2125103862 @default.
• W2078647607 hasRelatedWork W291138652 @default.
• W2078647607 hasVolume "36" @default.
• W2078647607 isParatext "false" @default.

• next