FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078648601> ?p ?o ?g. }

• W2078648601 endingPage "E14" @default.
• W2078648601 startingPage "E14" @default.
• W2078648601 abstract "Over the past 2 decades, advances in understanding the pathophysiology of spinal cord injury (SCI) have stimulated the recent emergence of several therapeutic strategies that are being examined in Phase I/II clinical trials. Ten randomized controlled trials examining methylprednisolone sodium succinate, tirilizad mesylate, monosialotetrahexosylganglioside, thyrotropin releasing hormone, gacyclidine, naloxone, and nimodipine have been completed. Although the primary outcomes in these trials were laregely negative, a secondary analysis of the North American Spinal Cord Injury Study II demonstrated that when administered within 8 hours of injury, methylprednisolone sodium succinate was associated with modest clinical benefits, which need to be weighed against potential complications. Thyrotropin releasing hormone (Phase II trial) and monosialotetrahexosylganglioside (Phase II and III trials) also showed some promise, but we are unaware of plans for future trials with these agents. These studies have, however, yielded many insights into the conduct of clinical trials for SCI. Several current or planned clinical trials are exploring interventions such as early surgical decompression (Surgical Treatment of Acute Spinal Cord Injury Study) and electrical field stimulation, neuroprotective strategies such as riluzole and minocycline, the inactivation of myelin inhibition by blocking Nogo and Rho, and the transplantation of various cellular substrates into the injured cord. Unfortunately, some experimental and poorly characterized SCI therapies are being offered outside a formal investigational structure, which will yield findings of limited scientific value and risk harm to patients with SCI who are understandably desperate for any intervention that might improve their function. Taken together, recent advances suggest that optimism for patients and clinicians alike is justified, as there is real hope that several safe and effective therapies for SCI may become available over the next decade." @default.
• W2078648601 created "2016-06-24" @default.
• W2078648601 creator A5007695442 @default.
• W2078648601 creator A5027259098 @default.
• W2078648601 creator A5043740917 @default.
• W2078648601 creator A5047977949 @default.
• W2078648601 date "2008-11-01" @default.
• W2078648601 modified "2023-10-12" @default.
• W2078648601 title "Protection and repair of the injured spinal cord: a review of completed, ongoing, and planned clinical trials for acute spinal cord injury" @default.
• W2078648601 cites W127351797 @default.
• W2078648601 cites W1506667049 @default.
• W2078648601 cites W1510677902 @default.
• W2078648601 cites W1566509581 @default.
• W2078648601 cites W1585651720 @default.
• W2078648601 cites W1661531354 @default.
• W2078648601 cites W183253557 @default.
• W2078648601 cites W1952053031 @default.
• W2078648601 cites W1963520280 @default.
• W2078648601 cites W1967015916 @default.
• W2078648601 cites W1970421251 @default.
• W2078648601 cites W1971304382 @default.
• W2078648601 cites W1976753753 @default.
• W2078648601 cites W1978779343 @default.
• W2078648601 cites W1979447754 @default.
• W2078648601 cites W1979620081 @default.
• W2078648601 cites W1981621010 @default.
• W2078648601 cites W1987408946 @default.
• W2078648601 cites W1990051906 @default.
• W2078648601 cites W1990203556 @default.
• W2078648601 cites W1992373160 @default.
• W2078648601 cites W1992442817 @default.
• W2078648601 cites W1994110032 @default.
• W2078648601 cites W1996449070 @default.
• W2078648601 cites W1999825042 @default.
• W2078648601 cites W2001092016 @default.
• W2078648601 cites W2001893348 @default.
• W2078648601 cites W2002510458 @default.
• W2078648601 cites W2003009591 @default.
• W2078648601 cites W2003687276 @default.
• W2078648601 cites W2004800810 @default.
• W2078648601 cites W2005573071 @default.
• W2078648601 cites W2006666533 @default.
• W2078648601 cites W2007237404 @default.
• W2078648601 cites W2007435025 @default.
• W2078648601 cites W2008607746 @default.
• W2078648601 cites W2008720843 @default.
• W2078648601 cites W2009191172 @default.
• W2078648601 cites W2013035816 @default.
• W2078648601 cites W2013550016 @default.
• W2078648601 cites W2015379496 @default.
• W2078648601 cites W2015406365 @default.
• W2078648601 cites W2016742969 @default.
• W2078648601 cites W2020122922 @default.
• W2078648601 cites W2022317887 @default.
• W2078648601 cites W2023402735 @default.
• W2078648601 cites W2025719428 @default.
• W2078648601 cites W2026036572 @default.
• W2078648601 cites W2026098217 @default.
• W2078648601 cites W2027350487 @default.
• W2078648601 cites W2029497518 @default.
• W2078648601 cites W2029768920 @default.
• W2078648601 cites W2031556847 @default.
• W2078648601 cites W2032413495 @default.
• W2078648601 cites W2033116866 @default.
• W2078648601 cites W2036717742 @default.
• W2078648601 cites W2036805729 @default.
• W2078648601 cites W2039334993 @default.
• W2078648601 cites W2041371057 @default.
• W2078648601 cites W2043773466 @default.
• W2078648601 cites W2045414227 @default.
• W2078648601 cites W2046029216 @default.
• W2078648601 cites W2047092154 @default.
• W2078648601 cites W2047768188 @default.
• W2078648601 cites W2049593742 @default.
• W2078648601 cites W2050353852 @default.
• W2078648601 cites W2050415048 @default.
• W2078648601 cites W2050807666 @default.
• W2078648601 cites W2051118774 @default.
• W2078648601 cites W2052041905 @default.
• W2078648601 cites W2052087711 @default.
• W2078648601 cites W2054934521 @default.
• W2078648601 cites W2055675455 @default.
• W2078648601 cites W2057436117 @default.
• W2078648601 cites W2058828879 @default.
• W2078648601 cites W2060476757 @default.
• W2078648601 cites W2060594848 @default.
• W2078648601 cites W2060977166 @default.
• W2078648601 cites W2063243573 @default.
• W2078648601 cites W2063877300 @default.
• W2078648601 cites W2063885093 @default.
• W2078648601 cites W2070842658 @default.
• W2078648601 cites W2071494502 @default.
• W2078648601 cites W2072316284 @default.
• W2078648601 cites W2072918197 @default.
• W2078648601 cites W2072963919 @default.
• W2078648601 cites W2073394261 @default.
• W2078648601 cites W2073541331 @default.
• W2078648601 cites W2073925210 @default.

• next