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- W2078650712 abstract "HUMAN LYMPHOBLASTOID INTERFERON (WellferonR) was administered to 33 patients in a phase I study. Patients received Wellferon intramuscularly every 12 hours for 14 doses in nine dosage levels ranging from 0.75 × 106 units to 50.0 × 106 units. Toxicity tended to be dose dependent and included fever/ chills, malaise, hematologic toxicity, and digestive tract toxicity. Thirty × 106 u q 12 h was felt to be the maximum tolerated dose. Three partial responses (renal cell carcinoma, diffuse histiocytic lymphoma, Hodgkin's disease) were achieved. Interferon rapidly (2 to 3 hours after the initial injection) reached peak serum levels which varied generally with dose and exceeded 500 u/ml at the 30 and 50 × 106 u dosages. Multiple doses of interferon resulted in cumulative peak levels substantially higher than first dose levels (>500 u/ml at dosages >3 × 106 u/ml and >1,500 u/ml at dosages ≥ 18 × 106 u). Interferon given at high dosages persisted up to 10 days beyond the final injection. Despite hematologic toxicity, inhibition of CFU-GM was not seen." @default.
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- W2078650712 date "1985-10-01" @default.
- W2078650712 modified "2023-09-25" @default.
- W2078650712 title "Human α-lymphoblastoid interferon" @default.
- W2078650712 doi "https://doi.org/10.1097/00000421-198510000-00013" @default.
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