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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078652280> ?p ?o ?g. }

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• W2078652280 abstract "Gonadotropin releasing hormone (GnRH) plays an important role in the biology of reproduction. The use of GnRH receptor antagonists has been reported in the literature for the treatment of breast, ovarian, and prostate cancers. In this article, we report the synthesis, in vitro characterization, pharmacokinetics, and pharmacodynamics of an orally bioavailable, potent, small molecule GnRH receptor antagonist N-{4,6-dimethoxy-2-[(3-morpholin-4-ylpropyl)amino]pyrimidin-5-yl}-5-[3,3,6-trimthyl-2,3-dihydro-1H-inden-5-yl)oxy]-2-furamide (compound 1)." @default.
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• W2078652280 date "2006-04-26" @default.
• W2078652280 modified "2023-10-14" @default.
• W2078652280 title "Discovery of a Novel, Orally Active, Small Molecule Gonadotropin-Releasing Hormone (GnRH) Receptor Antagonist" @default.
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• W2078652280 doi "https://doi.org/10.1021/jm060012g" @default.
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