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- W2078654003 endingPage "555" @default.
- W2078654003 startingPage "543" @default.
- W2078654003 abstract "Chemically induced cancer is a multi-step process involving damage to the genome initially followed by clonal expansion of the DNA damaged cell eventually leading to a neoplasm. Chemical carcinogens have been shown to impact at all of the stages of the tumorigenesis process. It has become apparent that chemical and physical agents that induce cancer may do so through several different cellular and molecular mechanisms. Epigenetic (nongenotoxic) chemical carcinogens are those agents that function to induce tumor formation by mechanisms exclusive of direct modification or damage to DNA. These agents appear to modulate cell growth and cell death and exhibit dose response relationships between exposure and tumor formation. The exact and/or exclusive mechanisms by which these agents function have not been established, however, changes in cell growth regulation and gene expression are important to tumor formation. This review focuses on several potential mechanisms and cellular processes that may be involved in nongenotoxic chemical carcinogenesis." @default.
- W2078654003 created "2016-06-24" @default.
- W2078654003 creator A5023743063 @default.
- W2078654003 creator A5059316371 @default.
- W2078654003 creator A5090063319 @default.
- W2078654003 date "2000-10-01" @default.
- W2078654003 modified "2023-10-08" @default.
- W2078654003 title "Epigenetic mechanisms of chemical carcinogenesis" @default.
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