Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078654071> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2078654071 endingPage "2022" @default.
- W2078654071 startingPage "2018" @default.
- W2078654071 abstract "Ryanodine receptor (RyR) activation by cyclic ADP-ribose (cADPR) is followed by homologous desensitization. Though poorly understood, this switching off process has provided a key experimental tool for determining the pathway through which cADPR mediates Ca(2+) release. Moreover, desensitization is likely to play an important role in shaping the complexities of Ca(2+) signaling involving cADPR, for example, localized release events and propagated waves. Using the sea urchin egg, we unmask a role of calmodulin, a component of the RyR complex and a key cofactor for cADPR activity, during RyR/cADPR desensitization. Recovery from desensitization in calmodulin-depleted purified endoplasmic reticulum (microsomes) is severely impaired compared to that in crude egg homogenates. An active, soluble factor, identified as calmodulin, is required to restore the capacity of microsomes to recover from desensitization. Calmodulin mediates recovery in a manner that tightly parallels its time course of association with the RyR. Conversely, direct measurement of calmodulin binding to microsomes reveals a loss of specific binding during cADPR, but not IP(3), desensitization. Our results support a mechanism in which cycles of calmodulin dissociation and reassociation to an endoplasmic reticulum protein, most likely the RyR itself, mediate RyR/cADPR desensitization and resensitization, respectively." @default.
- W2078654071 created "2016-06-24" @default.
- W2078654071 creator A5013996756 @default.
- W2078654071 creator A5026573711 @default.
- W2078654071 creator A5066007150 @default.
- W2078654071 creator A5067168449 @default.
- W2078654071 creator A5079677837 @default.
- W2078654071 date "2002-12-01" @default.
- W2078654071 modified "2023-09-24" @default.
- W2078654071 title "Calmodulin Dissociation Mediates Desensitization of the cADPR-Induced Ca2+ Release Mechanism" @default.
- W2078654071 cites W1963403501 @default.
- W2078654071 cites W1964597849 @default.
- W2078654071 cites W1975992025 @default.
- W2078654071 cites W1989847738 @default.
- W2078654071 cites W1991753089 @default.
- W2078654071 cites W2006265135 @default.
- W2078654071 cites W2012467728 @default.
- W2078654071 cites W2012753116 @default.
- W2078654071 cites W2026452617 @default.
- W2078654071 cites W2026571586 @default.
- W2078654071 cites W2040593177 @default.
- W2078654071 cites W2046477201 @default.
- W2078654071 cites W2085063650 @default.
- W2078654071 cites W2093144498 @default.
- W2078654071 cites W2112483397 @default.
- W2078654071 cites W2117527010 @default.
- W2078654071 cites W2160754842 @default.
- W2078654071 cites W2162432548 @default.
- W2078654071 cites W2164715751 @default.
- W2078654071 cites W2187616507 @default.
- W2078654071 cites W4230364809 @default.
- W2078654071 doi "https://doi.org/10.1016/s0960-9822(02)01335-0" @default.
- W2078654071 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12477390" @default.
- W2078654071 hasPublicationYear "2002" @default.
- W2078654071 type Work @default.
- W2078654071 sameAs 2078654071 @default.
- W2078654071 citedByCount "24" @default.
- W2078654071 countsByYear W20786540712012 @default.
- W2078654071 countsByYear W20786540712013 @default.
- W2078654071 countsByYear W20786540712014 @default.
- W2078654071 countsByYear W20786540712019 @default.
- W2078654071 countsByYear W20786540712020 @default.
- W2078654071 countsByYear W20786540712022 @default.
- W2078654071 crossrefType "journal-article" @default.
- W2078654071 hasAuthorship W2078654071A5013996756 @default.
- W2078654071 hasAuthorship W2078654071A5026573711 @default.
- W2078654071 hasAuthorship W2078654071A5066007150 @default.
- W2078654071 hasAuthorship W2078654071A5067168449 @default.
- W2078654071 hasAuthorship W2078654071A5079677837 @default.
- W2078654071 hasBestOaLocation W20786540711 @default.
- W2078654071 hasConcept C113217602 @default.
- W2078654071 hasConcept C12554922 @default.
- W2078654071 hasConcept C158617107 @default.
- W2078654071 hasConcept C170493617 @default.
- W2078654071 hasConcept C181199279 @default.
- W2078654071 hasConcept C2779779143 @default.
- W2078654071 hasConcept C29688787 @default.
- W2078654071 hasConcept C55493867 @default.
- W2078654071 hasConcept C86803240 @default.
- W2078654071 hasConcept C87644729 @default.
- W2078654071 hasConcept C95444343 @default.
- W2078654071 hasConceptScore W2078654071C113217602 @default.
- W2078654071 hasConceptScore W2078654071C12554922 @default.
- W2078654071 hasConceptScore W2078654071C158617107 @default.
- W2078654071 hasConceptScore W2078654071C170493617 @default.
- W2078654071 hasConceptScore W2078654071C181199279 @default.
- W2078654071 hasConceptScore W2078654071C2779779143 @default.
- W2078654071 hasConceptScore W2078654071C29688787 @default.
- W2078654071 hasConceptScore W2078654071C55493867 @default.
- W2078654071 hasConceptScore W2078654071C86803240 @default.
- W2078654071 hasConceptScore W2078654071C87644729 @default.
- W2078654071 hasConceptScore W2078654071C95444343 @default.
- W2078654071 hasIssue "23" @default.
- W2078654071 hasLocation W20786540711 @default.
- W2078654071 hasLocation W20786540712 @default.
- W2078654071 hasOpenAccess W2078654071 @default.
- W2078654071 hasPrimaryLocation W20786540711 @default.
- W2078654071 hasRelatedWork W1509170501 @default.
- W2078654071 hasRelatedWork W1979611590 @default.
- W2078654071 hasRelatedWork W2062131013 @default.
- W2078654071 hasRelatedWork W2078654071 @default.
- W2078654071 hasRelatedWork W2164609608 @default.
- W2078654071 hasRelatedWork W2809239518 @default.
- W2078654071 hasRelatedWork W2971559163 @default.
- W2078654071 hasRelatedWork W3004830544 @default.
- W2078654071 hasRelatedWork W4319590338 @default.
- W2078654071 hasRelatedWork W4319917298 @default.
- W2078654071 hasVolume "12" @default.
- W2078654071 isParatext "false" @default.
- W2078654071 isRetracted "false" @default.
- W2078654071 magId "2078654071" @default.
- W2078654071 workType "article" @default.