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• W2078656599 abstract "<h3>Context</h3>The Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation (COURAGE) study, which provided optimal medical therapy (OMT) to all patients and demonstrated no incremental advantage of percutaneous coronary intervention (PCI) on outcomes other than angina-related quality of life in stable coronary artery disease (CAD), suggests that a trial of OMT is warranted before PCI. It is unknown to what degree OMT is applied before PCI in routine practice or whether its use increased after the COURAGE trial.<h3>Objective</h3>To examine the use of OMT in patients with stable angina undergoing PCI before and after the publication of the COURAGE trial.<h3>Design, Setting, and Participants</h3>An observational study of patients with stable CAD undergoing PCI in the National Cardiovascular Data Registry between September 1, 2005, and June 30, 2009. Analysis compared use of OMT, both before PCI and at the time of discharge, before and after the publication of the COURAGE trial. Optimal medical therapy was defined as either being prescribed or having a documented contraindication to all medicines (antiplatelet agent, β-blocker, and statin).<h3>Main Outcome Measures</h3>Rates of OMT before PCI and at discharge (following PCI) between the 2 study periods.<h3>Results</h3>Among all 467 211 patients (173 416 before [37.1%] and 293 795 after [62.9%] the COURAGE trial) meeting study criteria, OMT was used in 206 569 patients (44.2%; 95% confidence interval [CI], 44.1%-44.4%) before PCI and in 303 864 patients (65.0%; 95% CI, 64.9%-65.2%) at discharge following PCI (P < .001). Before PCI, OMT was applied in 75 381 patients (43.5%; 95% CI, 43.2%-43.7%) before the COURAGE trial and in 131 188 patients (44.7%; 95% CI, 44.5%-44.8%) after the COURAGE trial (P < .001). The use of OMT at discharge following PCI before and after the COURAGE trial was 63.5% (95% CI, 63.3%-63.7%) and 66.0% (95% CI, 65.8%-66.1%), respectively (P < .001).<h3>Conclusion</h3>Among patients with stable CAD undergoing PCI, less than half were receiving OMT before PCI and approximately two-thirds were receiving OMT at discharge following PCI, with relatively little change in these practice patterns after publication of the COURAGE trial." @default.
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• W2078656599 date "2011-05-11" @default.
• W2078656599 modified "2023-10-18" @default.
• W2078656599 title "Patterns and Intensity of Medical Therapy in Patients Undergoing Percutaneous Coronary Intervention" @default.
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• W2078656599 doi "https://doi.org/10.1001/jama.2011.601" @default.
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