FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078656837> ?p ?o ?g. }

• W2078656837 endingPage "746" @default.
• W2078656837 startingPage "742" @default.
• W2078656837 abstract "The spectral characteristics in aqueous solution of a number of xanthine derivatives were found to be influenced by the presence of bovine and human serum albumin. The observed effects were assumed to be due to the binding of the xanthines by the protein. Changes in spectra were thus used as the basis for an experimental method for determining the extent and nature of the small molecule-protein interaction. The effects of temperature, pH, and protein modification on binding behavior were studied. Comparative studies on a number of structurally different xanthines were conducted. The results indicate that a rather specific orientation of the protein molecule was required for optimal interaction. Expansion or other configurational changes induced by pH or temperature effects resulted in decreased binding. The binding site appears to contain a grouping which can hydrogen-bond with the xanthine. The participation of other types of interaction forces are suggested also. The spectral characteristics in aqueous solution of a number of xanthine derivatives were found to be influenced by the presence of bovine and human serum albumin. The observed effects were assumed to be due to the binding of the xanthines by the protein. Changes in spectra were thus used as the basis for an experimental method for determining the extent and nature of the small molecule-protein interaction. The effects of temperature, pH, and protein modification on binding behavior were studied. Comparative studies on a number of structurally different xanthines were conducted. The results indicate that a rather specific orientation of the protein molecule was required for optimal interaction. Expansion or other configurational changes induced by pH or temperature effects resulted in decreased binding. The binding site appears to contain a grouping which can hydrogen-bond with the xanthine. The participation of other types of interaction forces are suggested also." @default.
• W2078656837 created "2016-06-24" @default.
• W2078656837 creator A5039612846 @default.
• W2078656837 creator A5054172292 @default.
• W2078656837 date "1965-05-01" @default.
• W2078656837 modified "2023-09-26" @default.
• W2078656837 title "Interactions of Xanthine Derivatives with Bovine Serum Albumin II" @default.
• W2078656837 cites W1907732933 @default.
• W2078656837 cites W1983649348 @default.
• W2078656837 cites W2013522560 @default.
• W2078656837 cites W2062664123 @default.
• W2078656837 cites W2323957424 @default.
• W2078656837 cites W2329737112 @default.
• W2078656837 cites W2421596730 @default.
• W2078656837 cites W72664020 @default.
• W2078656837 doi "https://doi.org/10.1002/jps.2600540517" @default.
• W2078656837 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/5845888" @default.
• W2078656837 hasPublicationYear "1965" @default.
• W2078656837 type Work @default.
• W2078656837 sameAs 2078656837 @default.
• W2078656837 citedByCount "11" @default.
• W2078656837 countsByYear W20786568372016 @default.
• W2078656837 crossrefType "journal-article" @default.
• W2078656837 hasAuthorship W2078656837A5039612846 @default.
• W2078656837 hasAuthorship W2078656837A5054172292 @default.
• W2078656837 hasConcept C112887158 @default.
• W2078656837 hasConcept C147597530 @default.
• W2078656837 hasConcept C165616093 @default.
• W2078656837 hasConcept C178790620 @default.
• W2078656837 hasConcept C181199279 @default.
• W2078656837 hasConcept C184651966 @default.
• W2078656837 hasConcept C185592680 @default.
• W2078656837 hasConcept C2779470414 @default.
• W2078656837 hasConcept C32909587 @default.
• W2078656837 hasConcept C55493867 @default.
• W2078656837 hasConcept C62614982 @default.
• W2078656837 hasConcept C86807702 @default.
• W2078656837 hasConceptScore W2078656837C112887158 @default.
• W2078656837 hasConceptScore W2078656837C147597530 @default.
• W2078656837 hasConceptScore W2078656837C165616093 @default.
• W2078656837 hasConceptScore W2078656837C178790620 @default.
• W2078656837 hasConceptScore W2078656837C181199279 @default.
• W2078656837 hasConceptScore W2078656837C184651966 @default.
• W2078656837 hasConceptScore W2078656837C185592680 @default.
• W2078656837 hasConceptScore W2078656837C2779470414 @default.
• W2078656837 hasConceptScore W2078656837C32909587 @default.
• W2078656837 hasConceptScore W2078656837C55493867 @default.
• W2078656837 hasConceptScore W2078656837C62614982 @default.
• W2078656837 hasConceptScore W2078656837C86807702 @default.
• W2078656837 hasIssue "5" @default.
• W2078656837 hasLocation W20786568371 @default.
• W2078656837 hasLocation W20786568372 @default.
• W2078656837 hasOpenAccess W2078656837 @default.
• W2078656837 hasPrimaryLocation W20786568371 @default.
• W2078656837 hasRelatedWork W2076609698 @default.
• W2078656837 hasRelatedWork W2082831552 @default.
• W2078656837 hasRelatedWork W2090666343 @default.
• W2078656837 hasRelatedWork W2093764384 @default.
• W2078656837 hasRelatedWork W2234329888 @default.
• W2078656837 hasRelatedWork W2367613624 @default.
• W2078656837 hasRelatedWork W2381494368 @default.
• W2078656837 hasRelatedWork W2383441512 @default.
• W2078656837 hasRelatedWork W3006477997 @default.
• W2078656837 hasRelatedWork W4254261482 @default.
• W2078656837 hasVolume "54" @default.
• W2078656837 isParatext "false" @default.
• W2078656837 isRetracted "false" @default.
• W2078656837 magId "2078656837" @default.
• W2078656837 workType "article" @default.