FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078657639> ?p ?o ?g. }

• W2078657639 endingPage "904" @default.
• W2078657639 startingPage "891" @default.
• W2078657639 abstract "Analysis of the mechanisms that control epithelial polarization has revealed that cues for polarization are mediated by transmembrane proteins that operate at the apical, lateral, or basal surface of epithelial cells. Whereas for any given epithelial cell type only one or two polarization systems have been identified to date, we report here that the follicular epithelium in Drosophila ovaries uses three different polarization mechanisms, each operating at one of the three main epithelial surface domains. The follicular epithelium arises through a mesenchymal-epithelial transition. Contact with the basement membrane provides an initial polarization cue that leads to the formation of a basal membrane domain. Moreover, we use mosaic analysis to show that Crumbs (Crb) is required for the formation and maintenance of the follicular epithelium. Crb localizes to the apical membrane of follicle cells that is in contact with germline cells. Contact to the germline is required for the accumulation of Crb in follicle cells. Discs Lost (Dlt), a cytoplasmic PDZ domain protein that was shown to interact with the cytoplasmic tail of Crb, overlaps precisely in its distribution with Crb, as shown by immunoelectron microscopy. Crb localization depends on Dlt, whereas Dlt uses Crb-dependent and -independent mechanisms for apical targeting. Finally, we show that the cadherin-catenin complex is not required for the formation of the follicular epithelium, but only for its maintenance. Loss of cadherin-based adherens junctions caused by armadillo (beta-catenin) mutations results in a disruption of the lateral spectrin and actin cytoskeleton. Also Crb and the apical spectrin cytoskeleton are lost from armadillo mutant follicle cells. Together with previous data showing that Crb is required for the formation of a zonula adherens, these findings indicate a mutual dependency of apical and lateral polarization mechanisms." @default.
• W2078657639 created "2016-06-24" @default.
• W2078657639 creator A5018488437 @default.
• W2078657639 creator A5029519500 @default.
• W2078657639 creator A5074205395 @default.
• W2078657639 creator A5083095386 @default.
• W2078657639 date "2000-11-13" @default.
• W2078657639 modified "2023-10-17" @default.
• W2078657639 title "Apical, Lateral, and Basal Polarization Cues Contribute to the Development of the Follicular Epithelium during <i>Drosophila</i> Oogenesis" @default.
• W2078657639 cites W1555563809 @default.
• W2078657639 cites W1565206009 @default.
• W2078657639 cites W1793536857 @default.
• W2078657639 cites W1835871649 @default.
• W2078657639 cites W1928474359 @default.
• W2078657639 cites W1966032423 @default.
• W2078657639 cites W1969694933 @default.
• W2078657639 cites W1971855104 @default.
• W2078657639 cites W1973131553 @default.
• W2078657639 cites W1976577398 @default.
• W2078657639 cites W1984121303 @default.
• W2078657639 cites W1985339304 @default.
• W2078657639 cites W2007372895 @default.
• W2078657639 cites W2008297562 @default.
• W2078657639 cites W2012569825 @default.
• W2078657639 cites W2013791364 @default.
• W2078657639 cites W2015114060 @default.
• W2078657639 cites W2017198154 @default.
• W2078657639 cites W2020773645 @default.
• W2078657639 cites W2026835299 @default.
• W2078657639 cites W2030945799 @default.
• W2078657639 cites W2039513425 @default.
• W2078657639 cites W2039595790 @default.
• W2078657639 cites W2039706860 @default.
• W2078657639 cites W2041498658 @default.
• W2078657639 cites W2045263227 @default.
• W2078657639 cites W2048529602 @default.
• W2078657639 cites W2055083701 @default.
• W2078657639 cites W2056641721 @default.
• W2078657639 cites W2057974199 @default.
• W2078657639 cites W2060006253 @default.
• W2078657639 cites W2070295283 @default.
• W2078657639 cites W2072509914 @default.
• W2078657639 cites W2076467199 @default.
• W2078657639 cites W2077159019 @default.
• W2078657639 cites W2077970848 @default.
• W2078657639 cites W2092125592 @default.
• W2078657639 cites W2097276658 @default.
• W2078657639 cites W2097286538 @default.
• W2078657639 cites W2110881251 @default.
• W2078657639 cites W2112310659 @default.
• W2078657639 cites W2112494447 @default.
• W2078657639 cites W2114692975 @default.
• W2078657639 cites W2116355277 @default.
• W2078657639 cites W2119339052 @default.
• W2078657639 cites W2120015950 @default.
• W2078657639 cites W2121730967 @default.
• W2078657639 cites W2126582065 @default.
• W2078657639 cites W2127204620 @default.
• W2078657639 cites W2127996136 @default.
• W2078657639 cites W2128367954 @default.
• W2078657639 cites W2136032801 @default.
• W2078657639 cites W2140795059 @default.
• W2078657639 cites W2143415456 @default.
• W2078657639 cites W2144792264 @default.
• W2078657639 cites W2146934540 @default.
• W2078657639 cites W2157298899 @default.
• W2078657639 cites W2158624339 @default.
• W2078657639 cites W2161815712 @default.
• W2078657639 cites W2164026443 @default.
• W2078657639 cites W2169621308 @default.
• W2078657639 cites W2184390227 @default.
• W2078657639 cites W2187419003 @default.
• W2078657639 cites W2189187333 @default.
• W2078657639 cites W2299010115 @default.
• W2078657639 cites W2403513032 @default.
• W2078657639 doi "https://doi.org/10.1083/jcb.151.4.891" @default.
• W2078657639 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2169434" @default.
• W2078657639 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11076972" @default.
• W2078657639 hasPublicationYear "2000" @default.
• W2078657639 type Work @default.
• W2078657639 sameAs 2078657639 @default.
• W2078657639 citedByCount "188" @default.
• W2078657639 countsByYear W20786576392012 @default.
• W2078657639 countsByYear W20786576392013 @default.
• W2078657639 countsByYear W20786576392014 @default.
• W2078657639 countsByYear W20786576392015 @default.
• W2078657639 countsByYear W20786576392016 @default.
• W2078657639 countsByYear W20786576392017 @default.
• W2078657639 countsByYear W20786576392018 @default.
• W2078657639 countsByYear W20786576392019 @default.
• W2078657639 countsByYear W20786576392020 @default.
• W2078657639 countsByYear W20786576392021 @default.
• W2078657639 countsByYear W20786576392022 @default.
• W2078657639 countsByYear W20786576392023 @default.
• W2078657639 crossrefType "journal-article" @default.
• W2078657639 hasAuthorship W2078657639A5018488437 @default.
• W2078657639 hasAuthorship W2078657639A5029519500 @default.
• W2078657639 hasAuthorship W2078657639A5074205395 @default.

• next