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• W2078658043 abstract "Significance Nutritional bacterial endosymbionts are housed in specialized host cells and are partitioned from the host cell cytoplasm by a host-derived symbiosomal membrane. This cellular organization isolates bacterial symbionts from nutrient pools in the host cell and makes possible host control of nutrient supply to bacterial symbionts. Here, using the aphid– Buchnera nutritional endosymbiosis, we demonstrate that the most active host glutamine (precursor) transporter, Acyrthosiphon pisum glutamine transporter 1, is competitively inhibited by arginine (a Buchnera -synthesized end product). We propose a model of endosymbiosis regulation in which precursor transport is regulated by a symbiont-synthesized end product. Thus, we provide insights into the molecular mechanism of host control of bacterial endosymbiont essential nutrient biosynthesis." @default.
• W2078658043 created "2016-06-24" @default.
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• W2078658043 date "2013-12-23" @default.
• W2078658043 modified "2023-10-17" @default.
• W2078658043 title "Aphid amino acid transporter regulates glutamine supply to intracellular bacterial symbionts" @default.
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• W2078658043 doi "https://doi.org/10.1073/pnas.1306068111" @default.
• W2078658043 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3890774" @default.
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