Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078658424> ?p ?o ?g. }
- W2078658424 endingPage "224" @default.
- W2078658424 startingPage "220" @default.
- W2078658424 abstract "Diets that are low in certain essential amino acids (EAAs), whether owing to low protein content or poor protein quality, tend to down-regulate systemic IGF-I activity, boost thermogenesis, and suppress hepatic capacity for lipogenesis, while promoting hepatic fatty acid oxidation. It is proposed that for each EAA there is a regulatory protein in hepatocytes whose activity is repressed by adequate levels of its EAA; if one (or more) of these regulatory proteins is active, it serves as a signal of EAA deficiency which then mediates the aforementioned effects on IGF-I activity, thermogenesis, and hepatic fatty acid metabolism. Mechanisms which monitor EAA availability likewise play a role in appetite regulation, thus accounting for the fact that spontaneous calorie consumption tends to be lower on high-protein diets. Diets low in protein quantity or quality may decrease insulin secretion, an effect which should contribute to their impact on IGF-I activity and lipid metabolism. The fact that vegans ingest diets that tend to be relatively low in certain EAAs may play a key role in their characteristic leanness and their decreased risk for diabetes, coronary disease, and cancer." @default.
- W2078658424 created "2016-06-24" @default.
- W2078658424 creator A5064469464 @default.
- W2078658424 date "2001-02-01" @default.
- W2078658424 modified "2023-09-27" @default.
- W2078658424 title "Hepatic monitoring of essential amino acid availability may regulate IGF-I activity, thermogenesis, and fatty acid oxidation/synthesis" @default.
- W2078658424 cites W113202324 @default.
- W2078658424 cites W11489686 @default.
- W2078658424 cites W1576899066 @default.
- W2078658424 cites W1584787855 @default.
- W2078658424 cites W1615727075 @default.
- W2078658424 cites W167765145 @default.
- W2078658424 cites W1885750830 @default.
- W2078658424 cites W1889271863 @default.
- W2078658424 cites W1899776962 @default.
- W2078658424 cites W1905490022 @default.
- W2078658424 cites W1933893653 @default.
- W2078658424 cites W195890107 @default.
- W2078658424 cites W1963641653 @default.
- W2078658424 cites W1973030882 @default.
- W2078658424 cites W1998846189 @default.
- W2078658424 cites W1998890155 @default.
- W2078658424 cites W2006541976 @default.
- W2078658424 cites W2012258507 @default.
- W2078658424 cites W2025594648 @default.
- W2078658424 cites W2033352867 @default.
- W2078658424 cites W2040477979 @default.
- W2078658424 cites W2040735050 @default.
- W2078658424 cites W2044577412 @default.
- W2078658424 cites W2051883615 @default.
- W2078658424 cites W2058770775 @default.
- W2078658424 cites W2065570670 @default.
- W2078658424 cites W2072721559 @default.
- W2078658424 cites W2076818787 @default.
- W2078658424 cites W2084584177 @default.
- W2078658424 cites W2087877556 @default.
- W2078658424 cites W2094423915 @default.
- W2078658424 cites W2098686767 @default.
- W2078658424 cites W2100375191 @default.
- W2078658424 cites W2111522158 @default.
- W2078658424 cites W2129747400 @default.
- W2078658424 cites W2130776690 @default.
- W2078658424 cites W2132649686 @default.
- W2078658424 cites W2139365477 @default.
- W2078658424 cites W2140968135 @default.
- W2078658424 cites W2144038971 @default.
- W2078658424 cites W2152287533 @default.
- W2078658424 cites W2158465207 @default.
- W2078658424 cites W2161853022 @default.
- W2078658424 cites W2163365401 @default.
- W2078658424 cites W2166468702 @default.
- W2078658424 cites W2172275678 @default.
- W2078658424 cites W2314083343 @default.
- W2078658424 cites W2326490020 @default.
- W2078658424 cites W4230238995 @default.
- W2078658424 cites W4233062587 @default.
- W2078658424 cites W4245027770 @default.
- W2078658424 doi "https://doi.org/10.1054/mehy.2000.1154" @default.
- W2078658424 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11425291" @default.
- W2078658424 hasPublicationYear "2001" @default.
- W2078658424 type Work @default.
- W2078658424 sameAs 2078658424 @default.
- W2078658424 citedByCount "5" @default.
- W2078658424 countsByYear W20786584242014 @default.
- W2078658424 crossrefType "journal-article" @default.
- W2078658424 hasAuthorship W2078658424A5064469464 @default.
- W2078658424 hasConcept C126322002 @default.
- W2078658424 hasConcept C134018914 @default.
- W2078658424 hasConcept C141359234 @default.
- W2078658424 hasConcept C151279926 @default.
- W2078658424 hasConcept C185592680 @default.
- W2078658424 hasConcept C2776941171 @default.
- W2078658424 hasConcept C2778816673 @default.
- W2078658424 hasConcept C4733338 @default.
- W2078658424 hasConcept C511355011 @default.
- W2078658424 hasConcept C515207424 @default.
- W2078658424 hasConcept C543025807 @default.
- W2078658424 hasConcept C55493867 @default.
- W2078658424 hasConcept C62231903 @default.
- W2078658424 hasConcept C71924100 @default.
- W2078658424 hasConcept C75908981 @default.
- W2078658424 hasConcept C82714985 @default.
- W2078658424 hasConcept C86803240 @default.
- W2078658424 hasConceptScore W2078658424C126322002 @default.
- W2078658424 hasConceptScore W2078658424C134018914 @default.
- W2078658424 hasConceptScore W2078658424C141359234 @default.
- W2078658424 hasConceptScore W2078658424C151279926 @default.
- W2078658424 hasConceptScore W2078658424C185592680 @default.
- W2078658424 hasConceptScore W2078658424C2776941171 @default.
- W2078658424 hasConceptScore W2078658424C2778816673 @default.
- W2078658424 hasConceptScore W2078658424C4733338 @default.
- W2078658424 hasConceptScore W2078658424C511355011 @default.
- W2078658424 hasConceptScore W2078658424C515207424 @default.
- W2078658424 hasConceptScore W2078658424C543025807 @default.
- W2078658424 hasConceptScore W2078658424C55493867 @default.
- W2078658424 hasConceptScore W2078658424C62231903 @default.
- W2078658424 hasConceptScore W2078658424C71924100 @default.
- W2078658424 hasConceptScore W2078658424C75908981 @default.