Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078658866> ?p ?o ?g. }
- W2078658866 endingPage "854" @default.
- W2078658866 startingPage "841" @default.
- W2078658866 abstract "After two decades of study, we draw the conclusion that venom-gland phospholipase A2 (PLA2) isozymes, including PLA2 myotoxins of Crotalinae snakes, have evolved in an accelerated manner to acquire their diverse physiological activities. In this review, we describe how accelerated evolution of venom PLA2 isozymes was discovered. This type of evolution is fundamental for other venom isozyme systems. Accelerated evolution of venom PLA2 isozyme genes is due to rapid change in exons, but not in introns and the flanking regions, being completely opposite to the case of the ordinary isozyme genes. The molecular mechanism by which proper base substitutions had occurred in the particular sites of venom isozyme genes is a puzzle to be solved in future studies. It should be noted that accelerated evolution occurred until the isozymes had acquired their particular function and, since then, they have evolved with less frequent mutation, possibly for functional conservation. We also found that interisland mutations occurred in venom PLA2 isozymes. The relationships between mutation and its driving force are speculative and the real mechanism remains a mystery." @default.
- W2078658866 created "2016-06-24" @default.
- W2078658866 creator A5009995824 @default.
- W2078658866 creator A5036184823 @default.
- W2078658866 creator A5048031869 @default.
- W2078658866 creator A5081557565 @default.
- W2078658866 creator A5087879639 @default.
- W2078658866 date "2003-12-01" @default.
- W2078658866 modified "2023-10-01" @default.
- W2078658866 title "Molecular evolution of myotoxic phospholipases A2 from snake venom" @default.
- W2078658866 cites W1487525039 @default.
- W2078658866 cites W1501888177 @default.
- W2078658866 cites W1523847362 @default.
- W2078658866 cites W1577981179 @default.
- W2078658866 cites W1585634514 @default.
- W2078658866 cites W1591000273 @default.
- W2078658866 cites W1608557156 @default.
- W2078658866 cites W1696959307 @default.
- W2078658866 cites W1828105334 @default.
- W2078658866 cites W1869604255 @default.
- W2078658866 cites W1874316998 @default.
- W2078658866 cites W1903219535 @default.
- W2078658866 cites W1942341692 @default.
- W2078658866 cites W1975269273 @default.
- W2078658866 cites W1977125555 @default.
- W2078658866 cites W1977728729 @default.
- W2078658866 cites W1982950613 @default.
- W2078658866 cites W1993054962 @default.
- W2078658866 cites W1993378893 @default.
- W2078658866 cites W1996027687 @default.
- W2078658866 cites W2002468039 @default.
- W2078658866 cites W2005214845 @default.
- W2078658866 cites W2009015188 @default.
- W2078658866 cites W2009716889 @default.
- W2078658866 cites W2010146383 @default.
- W2078658866 cites W2018911373 @default.
- W2078658866 cites W2025763720 @default.
- W2078658866 cites W2030089617 @default.
- W2078658866 cites W2030175052 @default.
- W2078658866 cites W2030827633 @default.
- W2078658866 cites W2030996680 @default.
- W2078658866 cites W2032537883 @default.
- W2078658866 cites W2032598969 @default.
- W2078658866 cites W2035205204 @default.
- W2078658866 cites W2035406968 @default.
- W2078658866 cites W2036778572 @default.
- W2078658866 cites W2037211988 @default.
- W2078658866 cites W2039279067 @default.
- W2078658866 cites W2042308296 @default.
- W2078658866 cites W2043170716 @default.
- W2078658866 cites W2047533797 @default.
- W2078658866 cites W2047919626 @default.
- W2078658866 cites W2050944289 @default.
- W2078658866 cites W205163230 @default.
- W2078658866 cites W2052045701 @default.
- W2078658866 cites W2052788807 @default.
- W2078658866 cites W2054736264 @default.
- W2078658866 cites W2055802474 @default.
- W2078658866 cites W2056097440 @default.
- W2078658866 cites W2056643258 @default.
- W2078658866 cites W2057403631 @default.
- W2078658866 cites W2062148798 @default.
- W2078658866 cites W2063601036 @default.
- W2078658866 cites W2066319194 @default.
- W2078658866 cites W2068730855 @default.
- W2078658866 cites W2070288681 @default.
- W2078658866 cites W2071367312 @default.
- W2078658866 cites W2071403854 @default.
- W2078658866 cites W2073253218 @default.
- W2078658866 cites W2075096030 @default.
- W2078658866 cites W2076623143 @default.
- W2078658866 cites W2076877224 @default.
- W2078658866 cites W2080550444 @default.
- W2078658866 cites W2082253319 @default.
- W2078658866 cites W2087262080 @default.
- W2078658866 cites W2093396859 @default.
- W2078658866 cites W2109541097 @default.
- W2078658866 cites W2110557868 @default.
- W2078658866 cites W2126676144 @default.
- W2078658866 cites W2156946828 @default.
- W2078658866 cites W2160008508 @default.
- W2078658866 cites W2162165648 @default.
- W2078658866 cites W2176302391 @default.
- W2078658866 cites W2213900735 @default.
- W2078658866 cites W4230141118 @default.
- W2078658866 doi "https://doi.org/10.1016/j.toxicon.2003.11.003" @default.
- W2078658866 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15019486" @default.
- W2078658866 hasPublicationYear "2003" @default.
- W2078658866 type Work @default.
- W2078658866 sameAs 2078658866 @default.
- W2078658866 citedByCount "90" @default.
- W2078658866 countsByYear W20786588662012 @default.
- W2078658866 countsByYear W20786588662013 @default.
- W2078658866 countsByYear W20786588662014 @default.
- W2078658866 countsByYear W20786588662015 @default.
- W2078658866 countsByYear W20786588662016 @default.
- W2078658866 countsByYear W20786588662018 @default.
- W2078658866 countsByYear W20786588662019 @default.