FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078659300> ?p ?o ?g. }

• W2078659300 endingPage "172" @default.
• W2078659300 startingPage "165" @default.
• W2078659300 abstract "The relative ability of cocaine, tropacocaine and amphetamine to inhibit the uptake of [3H]norepinephrine (NE), [3H]dopamine (DA) and [3H]5-hydroxytryptamine (5HT) was examined in whole brain synaptosomes from BALB, C3H, C57BL and DBA inbred mouse strains. With inhibition of [3H]NE uptake, synaptosomes from BALB and C57 mice were substantially more sensitive to cocaine inhibition than those from DBA or C3H. Moreover, with BALB and C57 tissue, amphetamine was as potent as cocaine, whereas with C3H and DBA, amphetamine and tropacocaine were much less potent inhibitors of [3H]NE uptake. With respect to [3H]DA accumulation, synaptosomes from BALB, C57 and DBA were equally sensitive to cocaine inhibition, while C3H synaptosomes were significantly less sensitive. In each of the four strains, amphetamine was more potent than cocaine, and tropacocaine far less potent. The relative potencies of the three drugs varied significantly among the four strains. With [3H]5HT accumulation, synaptosomes from DBA were exquisitely sensitive to cocaine inhibition, followed by BALB and lastly by C57 and C3H. In each of these strains, amphetamine and tropacocaine were equipotent at [3H]5HT inhibition, and less potent than cocaine. The results suggest that there are pronounced genetic differences in sensitivity to monoamine uptake inhibition by cocaine, which may arise from genetic differences in either carrier topology or other site of cocaine interaction. The results further suggest that genetic behavioral differences to cocaine and amphetamine may involve complex neurotransmitter interactions." @default.
• W2078659300 created "2016-06-24" @default.
• W2078659300 creator A5018273854 @default.
• W2078659300 creator A5056787516 @default.
• W2078659300 date "1989-09-01" @default.
• W2078659300 modified "2023-09-23" @default.
• W2078659300 title "Differential inhibition of synaptosomal accumulation of [3H]-monoamines by cocaine, tropacocaine and amphetamine in four inbred strains of mice" @default.
• W2078659300 cites W1964909230 @default.
• W2078659300 cites W1966998460 @default.
• W2078659300 cites W1976870178 @default.
• W2078659300 cites W1977486844 @default.
• W2078659300 cites W1980606076 @default.
• W2078659300 cites W1982994467 @default.
• W2078659300 cites W1988393370 @default.
• W2078659300 cites W1995366839 @default.
• W2078659300 cites W1998128937 @default.
• W2078659300 cites W2000624476 @default.
• W2078659300 cites W2003023983 @default.
• W2078659300 cites W2005997674 @default.
• W2078659300 cites W2008995782 @default.
• W2078659300 cites W2010426328 @default.
• W2078659300 cites W2011429118 @default.
• W2078659300 cites W2014016902 @default.
• W2078659300 cites W2014872690 @default.
• W2078659300 cites W2018012039 @default.
• W2078659300 cites W2018079054 @default.
• W2078659300 cites W2020860451 @default.
• W2078659300 cites W2021308822 @default.
• W2078659300 cites W2027908699 @default.
• W2078659300 cites W2030078771 @default.
• W2078659300 cites W2030615926 @default.
• W2078659300 cites W2031108718 @default.
• W2078659300 cites W2031315948 @default.
• W2078659300 cites W2038235904 @default.
• W2078659300 cites W2042215048 @default.
• W2078659300 cites W2042354839 @default.
• W2078659300 cites W2044434845 @default.
• W2078659300 cites W2044757496 @default.
• W2078659300 cites W2047464854 @default.
• W2078659300 cites W2058763540 @default.
• W2078659300 cites W2059449602 @default.
• W2078659300 cites W2059691450 @default.
• W2078659300 cites W2060060495 @default.
• W2078659300 cites W2061418383 @default.
• W2078659300 cites W2075383766 @default.
• W2078659300 cites W2076636600 @default.
• W2078659300 cites W2077153133 @default.
• W2078659300 cites W2079263758 @default.
• W2078659300 cites W2095217951 @default.
• W2078659300 cites W2111666128 @default.
• W2078659300 cites W2165398609 @default.
• W2078659300 cites W2182363772 @default.
• W2078659300 cites W2235129190 @default.
• W2078659300 cites W2416279662 @default.
• W2078659300 cites W2417978726 @default.
• W2078659300 cites W2432195370 @default.
• W2078659300 cites W2470767627 @default.
• W2078659300 cites W33201649 @default.
• W2078659300 cites W74306928 @default.
• W2078659300 doi "https://doi.org/10.1016/0091-3057(89)90368-7" @default.
• W2078659300 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2626447" @default.
• W2078659300 hasPublicationYear "1989" @default.
• W2078659300 type Work @default.
• W2078659300 sameAs 2078659300 @default.
• W2078659300 citedByCount "19" @default.
• W2078659300 countsByYear W20786593002012 @default.
• W2078659300 countsByYear W20786593002014 @default.
• W2078659300 crossrefType "journal-article" @default.
• W2078659300 hasAuthorship W2078659300A5018273854 @default.
• W2078659300 hasAuthorship W2078659300A5056787516 @default.
• W2078659300 hasConcept C134018914 @default.
• W2078659300 hasConcept C170493617 @default.
• W2078659300 hasConcept C185592680 @default.
• W2078659300 hasConcept C187714386 @default.
• W2078659300 hasConcept C2775864247 @default.
• W2078659300 hasConcept C2776219046 @default.
• W2078659300 hasConcept C2777193897 @default.
• W2078659300 hasConcept C2778514916 @default.
• W2078659300 hasConcept C513476851 @default.
• W2078659300 hasConcept C55493867 @default.
• W2078659300 hasConcept C86803240 @default.
• W2078659300 hasConcept C98274493 @default.
• W2078659300 hasConceptScore W2078659300C134018914 @default.
• W2078659300 hasConceptScore W2078659300C170493617 @default.
• W2078659300 hasConceptScore W2078659300C185592680 @default.
• W2078659300 hasConceptScore W2078659300C187714386 @default.
• W2078659300 hasConceptScore W2078659300C2775864247 @default.
• W2078659300 hasConceptScore W2078659300C2776219046 @default.
• W2078659300 hasConceptScore W2078659300C2777193897 @default.
• W2078659300 hasConceptScore W2078659300C2778514916 @default.
• W2078659300 hasConceptScore W2078659300C513476851 @default.
• W2078659300 hasConceptScore W2078659300C55493867 @default.
• W2078659300 hasConceptScore W2078659300C86803240 @default.
• W2078659300 hasConceptScore W2078659300C98274493 @default.
• W2078659300 hasIssue "1" @default.
• W2078659300 hasLocation W20786593001 @default.
• W2078659300 hasLocation W20786593002 @default.
• W2078659300 hasOpenAccess W2078659300 @default.

• next