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- W2078659822 abstract "Abstract Aim A novel and quick HPTLC-densitometric method was developed for the simultaneous determination of Ketoprofen, Methyl Paraben, and Propyl Paraben. Methods Chromatographic separation of the drugs was performed on precoated silica gel 60 F 254 Merck plates using Toluene:Ethyl acetate:Glacial acetic acid (6.5:2.5:1.0 v/v/v) as a mobile phase. A TLC scanner set at 265 nm was used of Ketoprofen, Methyl Paraben, Propyl Paraben respectively were validated according to ICH guidelines. Forced degradation conditions of hydrolysis (neutral, acidic and alkaline), oxidation, photolysis and thermal stress, as suggested in the ICH guideline Q1A (R2). Results The three drugs were satisfactorily resolved with R f values of 0.33 ± 0.05, 0.54 ± 0.05, 0.71 ± 0.05 for Ketoprofen, Methyl Paraben, Propyl Paraben respectively. Calibration curves were polynomial in the range 200–1000 ng/band, 200–1500 ng/band, 100–600 ng/band, for Ketoprofen, Methyl Paraben, and Propyl Paraben respectively. Correlation coefficient ( r ) values were 0.9917, 0.9927, 0.9906 Ketoprofen, Methyl Paraben, Propyl Paraben respectively. The percentage recovery ranges from 99 to 101%. Conclusion A low relative standard deviation (" @default.
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- W2078659822 date "2013-09-01" @default.
- W2078659822 modified "2023-09-25" @default.
- W2078659822 title "Stability-indicating HPTLC method for simultaneous determination of Ketoprofen, Methyl Paraben and Propyl Paraben in gel formulation" @default.
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- W2078659822 doi "https://doi.org/10.1016/j.jopr.2013.09.004" @default.
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