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- W2078661519 abstract "Obstetrics is moving beyond genomics and into proteomics. The Plasma Proteome Project aims to comprehensively and quantitatively analyze plasma proteins to elucidate biomarkers for disease. The characterization of plasma proteins presents multiple challenges because of protein diversity and the large dynamic range of expression. The purpose of this study was to use a novel approach for proteomic analysis to identify differentially expressed proteins in the plasma of normal women and those with preeclampsia. Two-dimensional chromatography was employed to separate and analyze samples from normal women (n = 41) and those with preeclampsia (n = 41). The first dimension employed high-performance chromatofocusing to identify the isoelectric point, and the second dimension, high-resolution reverse-phase high-pressure liquid chromatography to provide protein hydrophobicity of each fraction. A 2D protein map was generated using software that displays the isoelectric point and the degree of hydrophobicity. The maps were used as pattern recognition tools to discern unique combinations of proteins expressed in plasma. The following two partial 2D protein maps represent the differential plasma proteome of normal pregnant women and those with preeclampsia. Dramatic differences between normal and preeclamptic plasma are observed. Interface with mass spectrometry using the liquid phase output allows protein analysis and identification. Plasma proteomic analysis using 2D chromatography revealed unique differential expression in preeclampsia. This novel approach can be used for the identification of biomarkers and patterns of biomarkers predictive of disease." @default.
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- W2078661519 date "2003-12-01" @default.
- W2078661519 modified "2023-09-25" @default.
- W2078661519 title "A proteomic approach for the identification of biological markers of preeclampsia" @default.
- W2078661519 doi "https://doi.org/10.1016/j.ajog.2003.10.110" @default.
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