Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078661656> ?p ?o ?g. }
- W2078661656 endingPage "148" @default.
- W2078661656 startingPage "137" @default.
- W2078661656 abstract "New therapies for chronic lymphocytic leukemia (CLL) are moving away from non-specific cytotoxic to more targeted approaches. The monoclonal antibody alemtuzumab induces responses in 33% to 43% of patients with relapsed or refractory disease, with 2-5% CR. Side effects include infusional reactions as well as immunosuppressive effects. Rituximab has limited activity in relapsed refractory patients, but response rates are comparable to follicular non-Hodgkin's lymphoma in untreated patients. Other antibodies in early phases of development include anti-CD23 [IDEC-152], anti-CD22 [epratuzumab], Hu1D10 [apolizumab], and anti-CD80 [anti-B7, IDEC-114]. Other agents that are being studied include denileukin diftitox fusion protein (Ontak), and bcl-2 antisense [G3139, Genasense]. The mechanism of action of the new drugs and their role in CLL, as well as the emergence of new prognostic markers are discussed." @default.
- W2078661656 created "2016-06-24" @default.
- W2078661656 creator A5009044758 @default.
- W2078661656 creator A5022925854 @default.
- W2078661656 date "2004-06-01" @default.
- W2078661656 modified "2023-10-10" @default.
- W2078661656 title "Novel therapies for chronic lymphocytic leukemia" @default.
- W2078661656 cites W1243376384 @default.
- W2078661656 cites W1429374962 @default.
- W2078661656 cites W1527161131 @default.
- W2078661656 cites W154103547 @default.
- W2078661656 cites W1564039428 @default.
- W2078661656 cites W1592975144 @default.
- W2078661656 cites W1833241997 @default.
- W2078661656 cites W1942856476 @default.
- W2078661656 cites W2004051439 @default.
- W2078661656 cites W2004825203 @default.
- W2078661656 cites W2025128734 @default.
- W2078661656 cites W2032423298 @default.
- W2078661656 cites W2037049243 @default.
- W2078661656 cites W2044556240 @default.
- W2078661656 cites W2052275340 @default.
- W2078661656 cites W2080951919 @default.
- W2078661656 cites W2084198387 @default.
- W2078661656 cites W2090975649 @default.
- W2078661656 cites W2099348990 @default.
- W2078661656 cites W2104334201 @default.
- W2078661656 cites W2109694492 @default.
- W2078661656 cites W2110422885 @default.
- W2078661656 cites W2111609050 @default.
- W2078661656 cites W2116262245 @default.
- W2078661656 cites W2130988210 @default.
- W2078661656 cites W2137804513 @default.
- W2078661656 cites W2143749371 @default.
- W2078661656 cites W2148766690 @default.
- W2078661656 cites W2152025286 @default.
- W2078661656 cites W2154253476 @default.
- W2078661656 cites W2161926682 @default.
- W2078661656 cites W2169167811 @default.
- W2078661656 cites W21789158 @default.
- W2078661656 cites W2239090104 @default.
- W2078661656 cites W2290539832 @default.
- W2078661656 cites W2318309282 @default.
- W2078661656 cites W2318933236 @default.
- W2078661656 cites W2326175431 @default.
- W2078661656 cites W2335889607 @default.
- W2078661656 cites W2395470388 @default.
- W2078661656 cites W4230324843 @default.
- W2078661656 cites W4241791800 @default.
- W2078661656 cites W4251235745 @default.
- W2078661656 cites W60865865 @default.
- W2078661656 doi "https://doi.org/10.1016/s0268-960x(03)00039-0" @default.
- W2078661656 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15010151" @default.
- W2078661656 hasPublicationYear "2004" @default.
- W2078661656 type Work @default.
- W2078661656 sameAs 2078661656 @default.
- W2078661656 citedByCount "29" @default.
- W2078661656 countsByYear W20786616562013 @default.
- W2078661656 countsByYear W20786616562016 @default.
- W2078661656 countsByYear W20786616562018 @default.
- W2078661656 countsByYear W20786616562022 @default.
- W2078661656 crossrefType "journal-article" @default.
- W2078661656 hasAuthorship W2078661656A5009044758 @default.
- W2078661656 hasAuthorship W2078661656A5022925854 @default.
- W2078661656 hasConcept C126322002 @default.
- W2078661656 hasConcept C142424586 @default.
- W2078661656 hasConcept C143998085 @default.
- W2078661656 hasConcept C159654299 @default.
- W2078661656 hasConcept C18031839 @default.
- W2078661656 hasConcept C203014093 @default.
- W2078661656 hasConcept C2777058707 @default.
- W2078661656 hasConcept C2777938653 @default.
- W2078661656 hasConcept C2778384904 @default.
- W2078661656 hasConcept C2778461978 @default.
- W2078661656 hasConcept C2779015954 @default.
- W2078661656 hasConcept C2779338263 @default.
- W2078661656 hasConcept C2780653079 @default.
- W2078661656 hasConcept C502942594 @default.
- W2078661656 hasConcept C71924100 @default.
- W2078661656 hasConcept C86803240 @default.
- W2078661656 hasConcept C87355193 @default.
- W2078661656 hasConceptScore W2078661656C126322002 @default.
- W2078661656 hasConceptScore W2078661656C142424586 @default.
- W2078661656 hasConceptScore W2078661656C143998085 @default.
- W2078661656 hasConceptScore W2078661656C159654299 @default.
- W2078661656 hasConceptScore W2078661656C18031839 @default.
- W2078661656 hasConceptScore W2078661656C203014093 @default.
- W2078661656 hasConceptScore W2078661656C2777058707 @default.
- W2078661656 hasConceptScore W2078661656C2777938653 @default.
- W2078661656 hasConceptScore W2078661656C2778384904 @default.
- W2078661656 hasConceptScore W2078661656C2778461978 @default.
- W2078661656 hasConceptScore W2078661656C2779015954 @default.
- W2078661656 hasConceptScore W2078661656C2779338263 @default.
- W2078661656 hasConceptScore W2078661656C2780653079 @default.
- W2078661656 hasConceptScore W2078661656C502942594 @default.
- W2078661656 hasConceptScore W2078661656C71924100 @default.
- W2078661656 hasConceptScore W2078661656C86803240 @default.
- W2078661656 hasConceptScore W2078661656C87355193 @default.