FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078662799> ?p ?o ?g. }

• W2078662799 endingPage "48" @default.
• W2078662799 startingPage "39" @default.
• W2078662799 abstract "There is growing evidence that Toxoplasma gondii modifies the behavior of its intermediate hosts. We investigated the molecular basis of these infection-induced behavioral changes, followed by five related behavioral tests to assess the extent of biological relevance. Gene expression signatures were generated in the frontal cortex of male and female mice during the latent stage of infection. We found marked sex-dependent expression differences in mice. In female mice, Toxoplasma infection altered the expression of genes involved in the development of the forebrain, neurogenesis, and sensory and motor coordination (i.e. downregulation of fatty acid-binding protein 7 and eyes absent homolog 1, upregulation of semaphorin 7A). In male mice, infection led mainly to modulation of genes associated with olfactory function (i.e. downregulation of a number of olfactory receptors and dopamine receptor D4, upregulation of slit homolog 1). Although infection appears to affect the olfactory function in male mice, it is the female but not male mice that exhibited attraction to cat odor. In contrast, infected male mice showed a deficit in social transmission of food preference. In contrast to males, infected females displayed locomotor hyperactivity in open field. General olfaction and sensorimotor gating were normal in both male and female infection. Our results indicate that the sex of the host plays a major role in determining variable brain and behavior changes following Toxoplasma infection. These observations are consistent with heterogeneity of neuropsychiatric outcomes of the infection in humans." @default.
• W2078662799 created "2016-06-24" @default.
• W2078662799 creator A5000091890 @default.
• W2078662799 creator A5003491418 @default.
• W2078662799 creator A5043772835 @default.
• W2078662799 creator A5047161742 @default.
• W2078662799 creator A5077226654 @default.
• W2078662799 creator A5084982602 @default.
• W2078662799 creator A5089101853 @default.
• W2078662799 creator A5090672084 @default.
• W2078662799 date "2012-03-01" @default.
• W2078662799 modified "2023-09-23" @default.
• W2078662799 title "Sex-specific changes in gene expression and behavior induced by chronic Toxoplasma infection in mice" @default.
• W2078662799 cites W1481332551 @default.
• W2078662799 cites W1526553984 @default.
• W2078662799 cites W1573822259 @default.
• W2078662799 cites W1964776833 @default.
• W2078662799 cites W1965935901 @default.
• W2078662799 cites W1974306636 @default.
• W2078662799 cites W1982763490 @default.
• W2078662799 cites W1998109533 @default.
• W2078662799 cites W1999150960 @default.
• W2078662799 cites W2001884602 @default.
• W2078662799 cites W2002561811 @default.
• W2078662799 cites W2006750357 @default.
• W2078662799 cites W2009822878 @default.
• W2078662799 cites W2019473457 @default.
• W2078662799 cites W2028205982 @default.
• W2078662799 cites W2031266456 @default.
• W2078662799 cites W2042080464 @default.
• W2078662799 cites W2045222291 @default.
• W2078662799 cites W2052690976 @default.
• W2078662799 cites W2053014372 @default.
• W2078662799 cites W2059230444 @default.
• W2078662799 cites W2060080235 @default.
• W2078662799 cites W2061172411 @default.
• W2078662799 cites W2064085128 @default.
• W2078662799 cites W2074562663 @default.
• W2078662799 cites W2082030185 @default.
• W2078662799 cites W2105555770 @default.
• W2078662799 cites W2108661083 @default.
• W2078662799 cites W2123087183 @default.
• W2078662799 cites W2135000328 @default.
• W2078662799 cites W2137534843 @default.
• W2078662799 cites W2147663724 @default.
• W2078662799 cites W2150003410 @default.
• W2078662799 cites W2151331628 @default.
• W2078662799 cites W2168020062 @default.
• W2078662799 cites W2169797840 @default.
• W2078662799 cites W2174730010 @default.
• W2078662799 cites W42172885 @default.
• W2078662799 doi "https://doi.org/10.1016/j.neuroscience.2011.12.051" @default.
• W2078662799 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22240252" @default.
• W2078662799 hasPublicationYear "2012" @default.
• W2078662799 type Work @default.
• W2078662799 sameAs 2078662799 @default.
• W2078662799 citedByCount "84" @default.
• W2078662799 countsByYear W20786627992012 @default.
• W2078662799 countsByYear W20786627992013 @default.
• W2078662799 countsByYear W20786627992014 @default.
• W2078662799 countsByYear W20786627992015 @default.
• W2078662799 countsByYear W20786627992016 @default.
• W2078662799 countsByYear W20786627992017 @default.
• W2078662799 countsByYear W20786627992018 @default.
• W2078662799 countsByYear W20786627992019 @default.
• W2078662799 countsByYear W20786627992020 @default.
• W2078662799 countsByYear W20786627992021 @default.
• W2078662799 countsByYear W20786627992022 @default.
• W2078662799 countsByYear W20786627992023 @default.
• W2078662799 crossrefType "journal-article" @default.
• W2078662799 hasAuthorship W2078662799A5000091890 @default.
• W2078662799 hasAuthorship W2078662799A5003491418 @default.
• W2078662799 hasAuthorship W2078662799A5043772835 @default.
• W2078662799 hasAuthorship W2078662799A5047161742 @default.
• W2078662799 hasAuthorship W2078662799A5077226654 @default.
• W2078662799 hasAuthorship W2078662799A5084982602 @default.
• W2078662799 hasAuthorship W2078662799A5089101853 @default.
• W2078662799 hasAuthorship W2078662799A5090672084 @default.
• W2078662799 hasConcept C104317684 @default.
• W2078662799 hasConcept C127561419 @default.
• W2078662799 hasConcept C134018914 @default.
• W2078662799 hasConcept C15744967 @default.
• W2078662799 hasConcept C159654299 @default.
• W2078662799 hasConcept C169760540 @default.
• W2078662799 hasConcept C203014093 @default.
• W2078662799 hasConcept C2778128430 @default.
• W2078662799 hasConcept C2779085643 @default.
• W2078662799 hasConcept C2779715522 @default.
• W2078662799 hasConcept C529278444 @default.
• W2078662799 hasConcept C54355233 @default.
• W2078662799 hasConcept C86803240 @default.
• W2078662799 hasConceptScore W2078662799C104317684 @default.
• W2078662799 hasConceptScore W2078662799C127561419 @default.
• W2078662799 hasConceptScore W2078662799C134018914 @default.
• W2078662799 hasConceptScore W2078662799C15744967 @default.
• W2078662799 hasConceptScore W2078662799C159654299 @default.
• W2078662799 hasConceptScore W2078662799C169760540 @default.
• W2078662799 hasConceptScore W2078662799C203014093 @default.

• next