FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078662945> ?p ?o ?g. }

• W2078662945 endingPage "261" @default.
• W2078662945 startingPage "255" @default.
• W2078662945 abstract "Epidemiological studies of arsenic-exposed populations have provided evidence that arsenic exposure in humans is associated with immunosuppression. Previously, we have reported that arsenite-induced toxicity is associated with the induction of autophagy in human lymphoblastoid cell lines (LCL). Autophagy is a cellular process that functions in the degradation of damaged cellular components, including protein aggregates formed by misfolded or damaged proteins. Accumulation of misfolded or damaged proteins in the endoplasmic reticulum (ER) lumen causes ER stress and activates the unfolded protein response (UPR). In an effort to investigate the mechanism of autophagy induction by arsenite in the LCL model, we examined the potential contribution of ER stress and activation of the UPR. LCL exposed to sodium arsenite for 8-days induced expression of UPR-activated genes, including CHOP and GRP78, at the RNA and the protein level. Evidence for activation of the three arms of the UPR was observed. The arsenite-induced activation of the UPR was associated with an accumulation of protein aggregates containing p62 and LC3, proteins with established roles in the sequestration and autophagic clearance of protein aggregates. Taken together, these data provide evidence that arsenite-induced autophagy is associated with the generation of ER stress, activation of the UPR, and formation of protein aggregates that may be targeted to the lysosome for degradation." @default.
• W2078662945 created "2016-06-24" @default.
• W2078662945 creator A5009148166 @default.
• W2078662945 creator A5063142070 @default.
• W2078662945 creator A5065958281 @default.
• W2078662945 creator A5066952730 @default.
• W2078662945 date "2012-10-01" @default.
• W2078662945 modified "2023-10-16" @default.
• W2078662945 title "Arsenite-induced autophagy is associated with proteotoxicity in human lymphoblastoid cells" @default.
• W2078662945 cites W1492924917 @default.
• W2078662945 cites W1602776657 @default.
• W2078662945 cites W1964194050 @default.
• W2078662945 cites W1975200363 @default.
• W2078662945 cites W1976531450 @default.
• W2078662945 cites W1980942517 @default.
• W2078662945 cites W1986093310 @default.
• W2078662945 cites W1986342078 @default.
• W2078662945 cites W2014268728 @default.
• W2078662945 cites W2014918593 @default.
• W2078662945 cites W2018082393 @default.
• W2078662945 cites W2046153858 @default.
• W2078662945 cites W2047763620 @default.
• W2078662945 cites W2056908824 @default.
• W2078662945 cites W2063197029 @default.
• W2078662945 cites W2078877797 @default.
• W2078662945 cites W2088103993 @default.
• W2078662945 cites W2090665217 @default.
• W2078662945 cites W2101072770 @default.
• W2078662945 cites W2114081164 @default.
• W2078662945 cites W2117875646 @default.
• W2078662945 cites W2120104710 @default.
• W2078662945 cites W2127848114 @default.
• W2078662945 cites W2127916470 @default.
• W2078662945 cites W2144065739 @default.
• W2078662945 cites W2146124002 @default.
• W2078662945 cites W2150043714 @default.
• W2078662945 cites W2150418491 @default.
• W2078662945 cites W2157778451 @default.
• W2078662945 cites W2158535498 @default.
• W2078662945 cites W2166957980 @default.
• W2078662945 cites W2418465511 @default.
• W2078662945 cites W4242743062 @default.
• W2078662945 doi "https://doi.org/10.1016/j.taap.2012.08.006" @default.
• W2078662945 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3462290" @default.
• W2078662945 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22959463" @default.
• W2078662945 hasPublicationYear "2012" @default.
• W2078662945 type Work @default.
• W2078662945 sameAs 2078662945 @default.
• W2078662945 citedByCount "33" @default.
• W2078662945 countsByYear W20786629452013 @default.
• W2078662945 countsByYear W20786629452014 @default.
• W2078662945 countsByYear W20786629452015 @default.
• W2078662945 countsByYear W20786629452016 @default.
• W2078662945 countsByYear W20786629452017 @default.
• W2078662945 countsByYear W20786629452019 @default.
• W2078662945 countsByYear W20786629452020 @default.
• W2078662945 countsByYear W20786629452021 @default.
• W2078662945 countsByYear W20786629452022 @default.
• W2078662945 countsByYear W20786629452023 @default.
• W2078662945 crossrefType "journal-article" @default.
• W2078662945 hasAuthorship W2078662945A5009148166 @default.
• W2078662945 hasAuthorship W2078662945A5063142070 @default.
• W2078662945 hasAuthorship W2078662945A5065958281 @default.
• W2078662945 hasAuthorship W2078662945A5066952730 @default.
• W2078662945 hasBestOaLocation W20786629452 @default.
• W2078662945 hasConcept C104317684 @default.
• W2078662945 hasConcept C105580179 @default.
• W2078662945 hasConcept C117838200 @default.
• W2078662945 hasConcept C136238340 @default.
• W2078662945 hasConcept C139447449 @default.
• W2078662945 hasConcept C149364088 @default.
• W2078662945 hasConcept C158617107 @default.
• W2078662945 hasConcept C178790620 @default.
• W2078662945 hasConcept C185592680 @default.
• W2078662945 hasConcept C190283241 @default.
• W2078662945 hasConcept C203522944 @default.
• W2078662945 hasConcept C2776104650 @default.
• W2078662945 hasConcept C2776305511 @default.
• W2078662945 hasConcept C2779495234 @default.
• W2078662945 hasConcept C2780096491 @default.
• W2078662945 hasConcept C502230775 @default.
• W2078662945 hasConcept C55493867 @default.
• W2078662945 hasConcept C78604142 @default.
• W2078662945 hasConcept C86803240 @default.
• W2078662945 hasConcept C95444343 @default.
• W2078662945 hasConceptScore W2078662945C104317684 @default.
• W2078662945 hasConceptScore W2078662945C105580179 @default.
• W2078662945 hasConceptScore W2078662945C117838200 @default.
• W2078662945 hasConceptScore W2078662945C136238340 @default.
• W2078662945 hasConceptScore W2078662945C139447449 @default.
• W2078662945 hasConceptScore W2078662945C149364088 @default.
• W2078662945 hasConceptScore W2078662945C158617107 @default.
• W2078662945 hasConceptScore W2078662945C178790620 @default.
• W2078662945 hasConceptScore W2078662945C185592680 @default.
• W2078662945 hasConceptScore W2078662945C190283241 @default.
• W2078662945 hasConceptScore W2078662945C203522944 @default.
• W2078662945 hasConceptScore W2078662945C2776104650 @default.
• W2078662945 hasConceptScore W2078662945C2776305511 @default.

• next