FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078663294> ?p ?o ?g. }

• W2078663294 endingPage "3993" @default.
• W2078663294 startingPage "3988" @default.
• W2078663294 abstract "p53, the tumor suppressor protein, functions as a dimer of dimers. However, how the tetramer binds to the DNA is still an open question. In the crystal structure, three copies of the p53 monomers (containing chains A, B, and C) were crystallized with the DNA-consensus element. Although the structure provides crucial data on the p53-DNA contacts, the active oligomeric state is unclear because the two dimeric (A-B and B-C) interfaces present in the crystal cannot both exist in the tetramer. Here, we address the question of which of these two dimeric interfaces may be more biologically relevant. We analyze the sequence and structural properties of the p53-p53 dimeric interfaces and carry out extensive molecular dynamics simulations of the crystal structures of the human and mouse p53 dimers. We find that the A-B interface residues are more conserved than those of the B-C. Molecular dynamics simulations show that the A-B interface can provide a stable DNA-binding motif in the dimeric state, unlike B-C. Our results indicate that the interface between chains A-B in the p53-DNA complex constitutes a better candidate for a stable biological interface, whereas the B-C interface is more likely to be due to crystal packing. Thus, they have significant implications toward our understanding of DNA binding by p53 as well as p53-mediated interactions with other proteins." @default.
• W2078663294 created "2016-06-24" @default.
• W2078663294 creator A5007480448 @default.
• W2078663294 creator A5025357844 @default.
• W2078663294 creator A5067447756 @default.
• W2078663294 creator A5074738968 @default.
• W2078663294 creator A5076498226 @default.
• W2078663294 creator A5089778846 @default.
• W2078663294 date "2005-02-28" @default.
• W2078663294 modified "2023-10-14" @default.
• W2078663294 title "Comparison of the protein–protein interfaces in the p53–DNA crystal structures: Towards elucidation of the biological interface" @default.
• W2078663294 cites W1608920950 @default.
• W2078663294 cites W1650797637 @default.
• W2078663294 cites W1967023837 @default.
• W2078663294 cites W1968420035 @default.
• W2078663294 cites W1974477141 @default.
• W2078663294 cites W1976261939 @default.
• W2078663294 cites W1982168027 @default.
• W2078663294 cites W1988332041 @default.
• W2078663294 cites W1991794210 @default.
• W2078663294 cites W1995180922 @default.
• W2078663294 cites W1996899753 @default.
• W2078663294 cites W1999122619 @default.
• W2078663294 cites W2013563062 @default.
• W2078663294 cites W2017984451 @default.
• W2078663294 cites W2027408247 @default.
• W2078663294 cites W2051419785 @default.
• W2078663294 cites W2056905437 @default.
• W2078663294 cites W2067174909 @default.
• W2078663294 cites W2089831930 @default.
• W2078663294 cites W2095717900 @default.
• W2078663294 cites W2095732342 @default.
• W2078663294 cites W2096276671 @default.
• W2078663294 cites W2103262188 @default.
• W2078663294 cites W2123575677 @default.
• W2078663294 cites W2137675878 @default.
• W2078663294 cites W2141114863 @default.
• W2078663294 cites W2143939925 @default.
• W2078663294 cites W2145647064 @default.
• W2078663294 cites W2152292155 @default.
• W2078663294 cites W2160690759 @default.
• W2078663294 cites W2162166182 @default.
• W2078663294 cites W2164083146 @default.
• W2078663294 cites W2167032932 @default.
• W2078663294 cites W2171190723 @default.
• W2078663294 cites W2323701068 @default.
• W2078663294 cites W39231010 @default.
• W2078663294 doi "https://doi.org/10.1073/pnas.0500215102" @default.
• W2078663294 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/554805" @default.
• W2078663294 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15738397" @default.
• W2078663294 hasPublicationYear "2005" @default.
• W2078663294 type Work @default.
• W2078663294 sameAs 2078663294 @default.
• W2078663294 citedByCount "29" @default.
• W2078663294 countsByYear W20786632942013 @default.
• W2078663294 countsByYear W20786632942015 @default.
• W2078663294 countsByYear W20786632942016 @default.
• W2078663294 countsByYear W20786632942018 @default.
• W2078663294 countsByYear W20786632942020 @default.
• W2078663294 countsByYear W20786632942022 @default.
• W2078663294 crossrefType "journal-article" @default.
• W2078663294 hasAuthorship W2078663294A5007480448 @default.
• W2078663294 hasAuthorship W2078663294A5025357844 @default.
• W2078663294 hasAuthorship W2078663294A5067447756 @default.
• W2078663294 hasAuthorship W2078663294A5074738968 @default.
• W2078663294 hasAuthorship W2078663294A5076498226 @default.
• W2078663294 hasAuthorship W2078663294A5089778846 @default.
• W2078663294 hasBestOaLocation W20786632942 @default.
• W2078663294 hasConcept C115624301 @default.
• W2078663294 hasConcept C12554922 @default.
• W2078663294 hasConcept C178790620 @default.
• W2078663294 hasConcept C181199279 @default.
• W2078663294 hasConcept C185592680 @default.
• W2078663294 hasConcept C2778886173 @default.
• W2078663294 hasConcept C2779546866 @default.
• W2078663294 hasConcept C552990157 @default.
• W2078663294 hasConcept C55493867 @default.
• W2078663294 hasConcept C71240020 @default.
• W2078663294 hasConcept C8010536 @default.
• W2078663294 hasConcept C86803240 @default.
• W2078663294 hasConceptScore W2078663294C115624301 @default.
• W2078663294 hasConceptScore W2078663294C12554922 @default.
• W2078663294 hasConceptScore W2078663294C178790620 @default.
• W2078663294 hasConceptScore W2078663294C181199279 @default.
• W2078663294 hasConceptScore W2078663294C185592680 @default.
• W2078663294 hasConceptScore W2078663294C2778886173 @default.
• W2078663294 hasConceptScore W2078663294C2779546866 @default.
• W2078663294 hasConceptScore W2078663294C552990157 @default.
• W2078663294 hasConceptScore W2078663294C55493867 @default.
• W2078663294 hasConceptScore W2078663294C71240020 @default.
• W2078663294 hasConceptScore W2078663294C8010536 @default.
• W2078663294 hasConceptScore W2078663294C86803240 @default.
• W2078663294 hasIssue "11" @default.
• W2078663294 hasLocation W20786632941 @default.
• W2078663294 hasLocation W20786632942 @default.
• W2078663294 hasLocation W20786632943 @default.
• W2078663294 hasLocation W20786632944 @default.
• W2078663294 hasOpenAccess W2078663294 @default.

• next