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- W2078663452 abstract "Invasion of peptide nucleic acid (PNA) is important to target a specific site in double-stranded DNA. However, it needs improvement in many ways such as sequence versatility and invasion efficiency. It is here reported that one 10-mer strand of alpha-lysine substituted peptide nucleic acid (PNA) efficiently invades double-stranded DNA (dsDNA) in the presence of single-strand binding protein (SSB) via Watson-Crick rule. According to the thermodynamic parameters in this study, highly efficient invasion was achieved by a favorable entropy change. The importance of preorganization of PNAs for efficient strand invasion is indicated." @default.
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- W2078663452 date "2009-09-01" @default.
- W2078663452 modified "2023-09-25" @default.
- W2078663452 title "Promotion of strand invasion by utilizing entropically-favored PNA" @default.
- W2078663452 doi "https://doi.org/10.1093/nass/nrp081" @default.
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