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- W2078663602 endingPage "1004" @default.
- W2078663602 startingPage "944" @default.
- W2078663602 abstract "Despite all the advances in diagnosis and treatment of breast cancer, a large number of patients suffer from late diagnosis or recurrence of their disease. Current available imaging modalities do not reveal micrometastasis and tumor biopsy is an invasive method to detect early stage or recurrent cancer, signifying the need for an inexpensive, non-invasive diagnostic modality. Cell-free tumor DNA (ctDNA) has been tried for early detection and targeted therapy of breast cancer, but its diagnostic and prognostic utility is still under investigation. This review summarizes the existing evidence on the use of ctDNA specifically in breast cancer, including detection methods, diagnostic accuracy, role in genetics and epigenetics evaluation of the tumor, and comparison with other biomarkers. Current evidence suggests that increasing levels of ctDNA in breast cancer can be of significant diagnostic value for early detection of breast cancer although the sensitivity and specificity of the methods is still suboptimal. Additionally, ctDNA allows for characterizing the tumor in a non-invasive way and monitor the response to therapy, although discordance of ctDNA results with direct biopsy (i.e. due to tumor heterogeneity) is still considered a notable limitation." @default.
- W2078663602 created "2016-06-24" @default.
- W2078663602 creator A5036540296 @default.
- W2078663602 creator A5051939968 @default.
- W2078663602 creator A5060519089 @default.
- W2078663602 date "2009-12-01" @default.
- W2078663602 modified "2023-10-18" @default.
- W2078663602 title "Breast Cancer in Premenopausal Women" @default.
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