FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078665080> ?p ?o ?g. }

• W2078665080 endingPage "296" @default.
• W2078665080 startingPage "286" @default.
• W2078665080 abstract "Long-term changes in brain gene expression have been identified in alcohol dependence, but underlying mechanisms remain unknown. Here, we examined the potential role of microRNAs (miRNAs) for persistent gene expression changes in the rat medial prefrontal cortex (mPFC) after a history of alcohol dependence. Two-bottle free-choice alcohol consumption increased following 7-week exposure to intermittent alcohol intoxication. A bioinformatic approach using microarray analysis, quantitative PCR (qPCR), bioinformatic analysis and microRNA–messenger RNA (mRNA) integrative analysis identified expression patterns indicative of a disruption in synaptic processes and neuroplasticity. About 41 rat miRNAs and 165 mRNAs in the mPFC were significantly altered after chronic alcohol exposure. A subset of the miRNAs and mRNAs was confirmed by qPCR. Gene ontology categories of differential expression pointed to functional processes commonly associated with neurotransmission, neuroadaptation and synaptic plasticity. microRNA–mRNA expression pairing identified 33 miRNAs putatively targeting 89 mRNAs suggesting transcriptional networks involved in axonal guidance and neurotransmitter signaling. Our results demonstrate a significant shift in microRNA expression patterns in the mPFC following a history of dependence. Owing to their global regulation of multiple downstream target transcripts, miRNAs may have a pivotal role in the reorganization of synaptic connections and long-term neuroadaptations in alcohol dependence. MicroRNA-mediated alterations of transcriptional networks may be involved in disrupted prefrontal control over alcohol drinking observed in alcoholic patients." @default.
• W2078665080 created "2016-06-24" @default.
• W2078665080 creator A5013945938 @default.
• W2078665080 creator A5017144752 @default.
• W2078665080 creator A5023738842 @default.
• W2078665080 creator A5028618478 @default.
• W2078665080 creator A5036114199 @default.
• W2078665080 creator A5055523904 @default.
• W2078665080 creator A5066140694 @default.
• W2078665080 creator A5072701110 @default.
• W2078665080 creator A5082797974 @default.
• W2078665080 date "2012-05-22" @default.
• W2078665080 modified "2023-10-15" @default.
• W2078665080 title "Coordinated dysregulation of mRNAs and microRNAs in the rat medial prefrontal cortex following a history of alcohol dependence" @default.
• W2078665080 cites W1523993111 @default.
• W2078665080 cites W1547308539 @default.
• W2078665080 cites W1579354630 @default.
• W2078665080 cites W1874911782 @default.
• W2078665080 cites W1898039515 @default.
• W2078665080 cites W1926838596 @default.
• W2078665080 cites W1933703028 @default.
• W2078665080 cites W1967695018 @default.
• W2078665080 cites W1982713269 @default.
• W2078665080 cites W1982871940 @default.
• W2078665080 cites W1994447924 @default.
• W2078665080 cites W1997969083 @default.
• W2078665080 cites W1998645824 @default.
• W2078665080 cites W2000670569 @default.
• W2078665080 cites W2001003536 @default.
• W2078665080 cites W2001029058 @default.
• W2078665080 cites W2003386202 @default.
• W2078665080 cites W2009548083 @default.
• W2078665080 cites W2015445474 @default.
• W2078665080 cites W2016319122 @default.
• W2078665080 cites W2018863274 @default.
• W2078665080 cites W2034205729 @default.
• W2078665080 cites W2039604186 @default.
• W2078665080 cites W2041509376 @default.
• W2078665080 cites W2044345058 @default.
• W2078665080 cites W2045358091 @default.
• W2078665080 cites W2063357209 @default.
• W2078665080 cites W2067381654 @default.
• W2078665080 cites W2069207606 @default.
• W2078665080 cites W2069303592 @default.
• W2078665080 cites W2074146823 @default.
• W2078665080 cites W2075455339 @default.
• W2078665080 cites W2077306356 @default.
• W2078665080 cites W2089198034 @default.
• W2078665080 cites W2091670456 @default.
• W2078665080 cites W2092126179 @default.
• W2078665080 cites W2097087580 @default.
• W2078665080 cites W2100258320 @default.
• W2078665080 cites W2104919785 @default.
• W2078665080 cites W2117802141 @default.
• W2078665080 cites W2121018683 @default.
• W2078665080 cites W2121965670 @default.
• W2078665080 cites W2122683221 @default.
• W2078665080 cites W2123907069 @default.
• W2078665080 cites W2125591713 @default.
• W2078665080 cites W2133968430 @default.
• W2078665080 cites W2138473891 @default.
• W2078665080 cites W2139349028 @default.
• W2078665080 cites W2140395780 @default.
• W2078665080 cites W2141092265 @default.
• W2078665080 cites W2141729181 @default.
• W2078665080 cites W2146701314 @default.
• W2078665080 cites W2146870031 @default.
• W2078665080 cites W2149385968 @default.
• W2078665080 cites W2153773787 @default.
• W2078665080 cites W2158682367 @default.
• W2078665080 cites W2162826156 @default.
• W2078665080 cites W2162855805 @default.
• W2078665080 cites W2171116855 @default.
• W2078665080 cites W30434064 @default.
• W2078665080 cites W4211252821 @default.
• W2078665080 cites W64657418 @default.
• W2078665080 doi "https://doi.org/10.1038/tpj.2012.17" @default.
• W2078665080 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3546132" @default.
• W2078665080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22614244" @default.
• W2078665080 hasPublicationYear "2012" @default.
• W2078665080 type Work @default.
• W2078665080 sameAs 2078665080 @default.
• W2078665080 citedByCount "86" @default.
• W2078665080 countsByYear W20786650802012 @default.
• W2078665080 countsByYear W20786650802013 @default.
• W2078665080 countsByYear W20786650802014 @default.
• W2078665080 countsByYear W20786650802015 @default.
• W2078665080 countsByYear W20786650802016 @default.
• W2078665080 countsByYear W20786650802017 @default.
• W2078665080 countsByYear W20786650802018 @default.
• W2078665080 countsByYear W20786650802019 @default.
• W2078665080 countsByYear W20786650802020 @default.
• W2078665080 countsByYear W20786650802021 @default.
• W2078665080 countsByYear W20786650802022 @default.
• W2078665080 countsByYear W20786650802023 @default.
• W2078665080 crossrefType "journal-article" @default.
• W2078665080 hasAuthorship W2078665080A5013945938 @default.
• W2078665080 hasAuthorship W2078665080A5017144752 @default.

• next