Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078666720> ?p ?o ?g. }
- W2078666720 endingPage "495" @default.
- W2078666720 startingPage "489" @default.
- W2078666720 abstract "Abstract CpG oligodeoxynucleotides (CpG-ODNs) affect innate and adaptive immune responses, including antigen presentation, costimulatory molecule expression, dendritic cell maturation, and induction of cytokines enhancing antibody-dependent cell-mediated cytotoxicity (ADCC). We conducted a phase 1 study evaluating 4 dose levels of a CpG-ODN (1018 ISS) with rituximab in 20 patients with relapsed non-Hodgkin lymphoma (NHL). Patients received CpG once a week for 4 weeks beginning after the second of 4 rituximab infusions. Adverse events were minimal. Quantitative polymerase chain reaction (PCR) measurements of a panel of genes inducible by CpG-ODN and interferons were performed on blood samples collected before and 24 hours after CpG. A dose-related increase was measured in the expression of several interferon–inducible genes after CpG and correlated with serum levels of 2′-5′ oligoadenylate synthetase (OAS), a validated interferon response marker. Genes induced selectively by interferon-γ (IFN-γ) were not significantly induced by CpG. In conclusion, we have defined a set of gene expression markers that provide a sensitive measure of biologic responses of patients to CpG therapy in a dose-related manner. Moreover, all the genes significantly induced by this CpG are regulated by type 1 interferons, providing insight into the dominant immune mechanisms in humans. CpG treatment resulted in no significant toxicity, providing rationale for further testing of this exciting combination immunotherapy approach to NHL." @default.
- W2078666720 created "2016-06-24" @default.
- W2078666720 creator A5019128517 @default.
- W2078666720 creator A5037942629 @default.
- W2078666720 creator A5038526399 @default.
- W2078666720 creator A5042598645 @default.
- W2078666720 creator A5059412829 @default.
- W2078666720 creator A5073116324 @default.
- W2078666720 creator A5074110466 @default.
- W2078666720 creator A5077671733 @default.
- W2078666720 creator A5082174975 @default.
- W2078666720 date "2005-01-15" @default.
- W2078666720 modified "2023-10-09" @default.
- W2078666720 title "Combination immunotherapy with a CpG oligonucleotide (1018 ISS) and rituximab in patients with non-Hodgkin lymphoma: increased interferon-α/β–inducible gene expression, without significant toxicity" @default.
- W2078666720 cites W1571520647 @default.
- W2078666720 cites W1592394199 @default.
- W2078666720 cites W1661544713 @default.
- W2078666720 cites W18573662 @default.
- W2078666720 cites W1912693401 @default.
- W2078666720 cites W1915689252 @default.
- W2078666720 cites W1917892434 @default.
- W2078666720 cites W1956007715 @default.
- W2078666720 cites W1965962344 @default.
- W2078666720 cites W1969617808 @default.
- W2078666720 cites W1984327456 @default.
- W2078666720 cites W1998668416 @default.
- W2078666720 cites W1999587028 @default.
- W2078666720 cites W2014909531 @default.
- W2078666720 cites W2019134347 @default.
- W2078666720 cites W2022581009 @default.
- W2078666720 cites W2027187105 @default.
- W2078666720 cites W2027374210 @default.
- W2078666720 cites W2028928436 @default.
- W2078666720 cites W2044102082 @default.
- W2078666720 cites W2044360617 @default.
- W2078666720 cites W2049653821 @default.
- W2078666720 cites W2050436579 @default.
- W2078666720 cites W2059949924 @default.
- W2078666720 cites W2063157305 @default.
- W2078666720 cites W2065316818 @default.
- W2078666720 cites W2074358355 @default.
- W2078666720 cites W2079756029 @default.
- W2078666720 cites W2082635925 @default.
- W2078666720 cites W2087144130 @default.
- W2078666720 cites W2098461957 @default.
- W2078666720 cites W2105270641 @default.
- W2078666720 cites W2114946770 @default.
- W2078666720 cites W2115351802 @default.
- W2078666720 cites W2116458521 @default.
- W2078666720 cites W2118011548 @default.
- W2078666720 cites W2128402413 @default.
- W2078666720 cites W2129664415 @default.
- W2078666720 cites W2140644802 @default.
- W2078666720 cites W2152627678 @default.
- W2078666720 cites W2158827553 @default.
- W2078666720 cites W2161122282 @default.
- W2078666720 cites W2165330836 @default.
- W2078666720 cites W2252316235 @default.
- W2078666720 cites W2256392563 @default.
- W2078666720 cites W2290539832 @default.
- W2078666720 cites W2338573834 @default.
- W2078666720 cites W2338816059 @default.
- W2078666720 cites W2418478757 @default.
- W2078666720 cites W33733012 @default.
- W2078666720 cites W60759546 @default.
- W2078666720 cites W90568390 @default.
- W2078666720 cites W2011810013 @default.
- W2078666720 doi "https://doi.org/10.1182/blood-2004-06-2156" @default.
- W2078666720 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15358617" @default.
- W2078666720 hasPublicationYear "2005" @default.
- W2078666720 type Work @default.
- W2078666720 sameAs 2078666720 @default.
- W2078666720 citedByCount "144" @default.
- W2078666720 countsByYear W20786667202012 @default.
- W2078666720 countsByYear W20786667202013 @default.
- W2078666720 countsByYear W20786667202014 @default.
- W2078666720 countsByYear W20786667202015 @default.
- W2078666720 countsByYear W20786667202016 @default.
- W2078666720 countsByYear W20786667202017 @default.
- W2078666720 countsByYear W20786667202018 @default.
- W2078666720 countsByYear W20786667202019 @default.
- W2078666720 countsByYear W20786667202020 @default.
- W2078666720 countsByYear W20786667202021 @default.
- W2078666720 countsByYear W20786667202022 @default.
- W2078666720 countsByYear W20786667202023 @default.
- W2078666720 crossrefType "journal-article" @default.
- W2078666720 hasAuthorship W2078666720A5019128517 @default.
- W2078666720 hasAuthorship W2078666720A5037942629 @default.
- W2078666720 hasAuthorship W2078666720A5038526399 @default.
- W2078666720 hasAuthorship W2078666720A5042598645 @default.
- W2078666720 hasAuthorship W2078666720A5059412829 @default.
- W2078666720 hasAuthorship W2078666720A5073116324 @default.
- W2078666720 hasAuthorship W2078666720A5074110466 @default.
- W2078666720 hasAuthorship W2078666720A5077671733 @default.
- W2078666720 hasAuthorship W2078666720A5082174975 @default.
- W2078666720 hasBestOaLocation W20786667201 @default.
- W2078666720 hasConcept C104317684 @default.
- W2078666720 hasConcept C140173407 @default.