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• W2078667038 startingPage "129" @default.
• W2078667038 abstract "An alcohol-induced change in serum transferrin glycosylation, termed carbohydrate-deficient transferrin (CDT), is widely used as a biomarker of heavy long-term drinking. This study examined the transferrin glycosylation profile and the risk for false-positive CDT results during pregnancy. Serum samples were collected from 24 healthy pregnant women starting in gestation week 9–21, throughout pregnancy, and 8 or more weeks after delivery. Altogether 171 sera (5–9 samples/person) were analysed. Transferrin glycoforms were quantified as a percentage of total transferrin, using an HPLC candidate reference method for CDT. During pregnancy, the relative disialo-, pentasialo- and hexasialotransferrin levels increased gradually, whereas trisialo- and tetrasialotransferrin were reduced. This effect was most pronounced in the third trimester. For disialotransferrin, the main target in CDT testing, initial values of 1.07 ± 0.17% (mean ± SD) increased to 1.61 ± 0.23% before delivery (~ 50% increase). Nine (38%) pregnant women reached %disialotransferrin values ≥ 1.7% (97.5th percentile for controls) but all results were < 2.0%. In the postpartum samples, all glycoform levels had returned towards the starting values. These results suggest that the cutoff for %disialotransferrin and %CDT employed to indicate heavy long-term drinking need to be raised slightly in pregnant women, to minimize the risk for false-positive results on CDT testing." @default.
• W2078667038 created "2016-06-24" @default.
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• W2078667038 creator A5063617371 @default.
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• W2078667038 date "2011-01-01" @default.
• W2078667038 modified "2023-10-16" @default.
• W2078667038 title "Changes in transferrin glycosylation during pregnancy may lead to false-positive carbohydrate-deficient transferrin (CDT) results in testing for riskful alcohol consumption" @default.
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• W2078667038 doi "https://doi.org/10.1016/j.cca.2010.09.022" @default.
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• W2078667038 hasPublicationYear "2011" @default.
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