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• W2078667545 abstract "You have accessJournal of UrologyKidney Cancer: Basic Research1 Apr 2011243 HISTONE DEACETYLASE INHIBITOR POTENTIATES SORAFENIB-INDUCED CELL DEATH IN RENAL CELL CARCINOMA CELL LINES Sungwoo Hong, Dalsan You, Kwang Hyun Kim, In Gab Jeong, Mi Joung Kim, Dongeun Kim, Jung Jin Hwang, Sejin Jang, Je-Hwan Lee, Jene Choi, Seonggu Ro, and Choung-Soo Kim Sungwoo HongSungwoo Hong Seoul, Korea, Republic of More articles by this author , Dalsan YouDalsan You Seoul, Korea, Republic of More articles by this author , Kwang Hyun KimKwang Hyun Kim Seoul, Korea, Republic of More articles by this author , In Gab JeongIn Gab Jeong Seoul, Korea, Republic of More articles by this author , Mi Joung KimMi Joung Kim Seoul, Korea, Republic of More articles by this author , Dongeun KimDongeun Kim Seoul, Korea, Republic of More articles by this author , Jung Jin HwangJung Jin Hwang Seoul, Korea, Republic of More articles by this author , Sejin JangSejin Jang Seoul, Korea, Republic of More articles by this author , Je-Hwan LeeJe-Hwan Lee Seoul, Korea, Republic of More articles by this author , Jene ChoiJene Choi Seoul, Korea, Republic of More articles by this author , Seonggu RoSeonggu Ro Seoul, Korea, Republic of More articles by this author , and Choung-Soo KimChoung-Soo Kim Seoul, Korea, Republic of More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.312AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES we analyzed the mechanism of cell death induced by the combination with histone deacetylase inhibitor (HDACI) and sorafenib in renal cell carcinoma (RCC) cell lines, and evaluated the usefulness of this combination for RCC treatment. METHODS RCC cells in NCI-60 cancer cell panel (786O, A490, ACHN, Caki-1, RXF393, SN12C, TK10 and UO31) were used to evaluate cell death induced by HDACI (belinostat and vorinostat) and their combination with sorafenib. Cell viability was measured by CellTiter 96® Aqueous One Solution Cell proliferation assay (MTS assay) and expression of protein was analyzed by Western blot. Combination indexes were calculated with CalcuSyn software. RESULTS Treatment with belinostat or vorinostat alone inhibited growth of 8 kinds of RCC cells in NCI-60 cancer cell panel, showing several micromolar concentrations of IC50s. These HDACIs increased the acetylation of histone 3 (H3) and tubulin, and activated caspase-8, -9, and -3 in Caki-1, 786O, SN12C, and UO31 RCC cells, indicating the induction of apoptosis. Pre-treatment of clear cell type RCC (CCRCC) Caki-1 and 786O cells with HDACIs followed by sorafenib showed synergistic anti-tumor effect, activation of caspases, and decrease in Mcl-1 and Bcl-xL, phopho-Erk, and VEGF in Caki-1 and 786O cells. CONCLUSIONS The present study results indicate that combination of HDACI and sorafenib increased apoptosis of RCC cells via intrinsic and extrinsic pathways by reducing the level of anti-apoptotic Bcl-2 family proteins, phospho-Erk and VEGF suggesting that this combination treatment may be a new approach to treat patients with CCRCC. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e98 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Sungwoo Hong Seoul, Korea, Republic of More articles by this author Dalsan You Seoul, Korea, Republic of More articles by this author Kwang Hyun Kim Seoul, Korea, Republic of More articles by this author In Gab Jeong Seoul, Korea, Republic of More articles by this author Mi Joung Kim Seoul, Korea, Republic of More articles by this author Dongeun Kim Seoul, Korea, Republic of More articles by this author Jung Jin Hwang Seoul, Korea, Republic of More articles by this author Sejin Jang Seoul, Korea, Republic of More articles by this author Je-Hwan Lee Seoul, Korea, Republic of More articles by this author Jene Choi Seoul, Korea, Republic of More articles by this author Seonggu Ro Seoul, Korea, Republic of More articles by this author Choung-Soo Kim Seoul, Korea, Republic of More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ..." @default.
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• W2078667545 title "243 HISTONE DEACETYLASE INHIBITOR POTENTIATES SORAFENIB-INDUCED CELL DEATH IN RENAL CELL CARCINOMA CELL LINES" @default.
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