FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078668253> ?p ?o ?g. }

• W2078668253 endingPage "7278" @default.
• W2078668253 startingPage "7273" @default.
• W2078668253 abstract "N4-Aminocytidine is a potent mutagen toward Escherichia coli and Salmonella typhimurium. It induced reversion of an amber mutant of phi X174 phage (am3) to the wild type. This reversion was shown to be exclusively due to the AT to GC transition. It is likely that N4-aminocytidine is metabolized within the bacterial cells into N4-aminodeoxycytidine 5'-triphosphate and this nucleotide is incorporated into DNA during the multiplication of the cells and the phages, thereby causing base-pair transitions. The molecular basis for this erroneous replication was obtained in studies of in vitro incorporation of N4-aminodeoxycytidine 5'-triphosphate into polynucleotides catalyzed by the E. coli DNA polymerase I large fragment. The results have shown that this cytosine analogue can be efficiently incorporated as a substitute of cytosine and that it can also be incorporated as a substitute of thymine. The ratio in the rate of the N4-aminocytosine nucleotide incorporation to that of natural nucleotide incorporation was 1/2 to cytosine and 1/30 to thymine. Furthermore, the N4-aminocytosine residues in the polynucleotide templates can be read by the enzyme as efficiently as cytosines, and guanines were incorporated opposite to them." @default.
• W2078668253 created "2016-06-24" @default.
• W2078668253 creator A5007084530 @default.
• W2078668253 creator A5018342071 @default.
• W2078668253 creator A5019637687 @default.
• W2078668253 creator A5025809212 @default.
• W2078668253 creator A5079226947 @default.
• W2078668253 date "1985-12-01" @default.
• W2078668253 modified "2023-09-27" @default.
• W2078668253 title "Mutagenesis by N4-aminocytidine: induction of AT to GC transition and its molecular mechanism" @default.
• W2078668253 cites W1541696918 @default.
• W2078668253 cites W1547038432 @default.
• W2078668253 cites W1567376454 @default.
• W2078668253 cites W1967946050 @default.
• W2078668253 cites W1969094530 @default.
• W2078668253 cites W1978020758 @default.
• W2078668253 cites W1992595091 @default.
• W2078668253 cites W1996126082 @default.
• W2078668253 cites W2000636067 @default.
• W2078668253 cites W2024759811 @default.
• W2078668253 cites W2046558492 @default.
• W2078668253 cites W2057352074 @default.
• W2078668253 cites W2057809835 @default.
• W2078668253 cites W2063134544 @default.
• W2078668253 cites W2066711410 @default.
• W2078668253 cites W2069445877 @default.
• W2078668253 cites W2074020252 @default.
• W2078668253 cites W2113960828 @default.
• W2078668253 cites W2130101148 @default.
• W2078668253 cites W2174994538 @default.
• W2078668253 cites W2332806975 @default.
• W2078668253 doi "https://doi.org/10.1021/bi00346a038" @default.
• W2078668253 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2935188" @default.
• W2078668253 hasPublicationYear "1985" @default.
• W2078668253 type Work @default.
• W2078668253 sameAs 2078668253 @default.
• W2078668253 citedByCount "28" @default.
• W2078668253 countsByYear W20786682532014 @default.
• W2078668253 countsByYear W20786682532017 @default.
• W2078668253 countsByYear W20786682532021 @default.
• W2078668253 crossrefType "journal-article" @default.
• W2078668253 hasAuthorship W2078668253A5007084530 @default.
• W2078668253 hasAuthorship W2078668253A5018342071 @default.
• W2078668253 hasAuthorship W2078668253A5019637687 @default.
• W2078668253 hasAuthorship W2078668253A5025809212 @default.
• W2078668253 hasAuthorship W2078668253A5079226947 @default.
• W2078668253 hasConcept C104317684 @default.
• W2078668253 hasConcept C111921641 @default.
• W2078668253 hasConcept C127716648 @default.
• W2078668253 hasConcept C143065580 @default.
• W2078668253 hasConcept C156719811 @default.
• W2078668253 hasConcept C16318435 @default.
• W2078668253 hasConcept C164965036 @default.
• W2078668253 hasConcept C185592680 @default.
• W2078668253 hasConcept C2756471 @default.
• W2078668253 hasConcept C2776023528 @default.
• W2078668253 hasConcept C2776639595 @default.
• W2078668253 hasConcept C2776858809 @default.
• W2078668253 hasConcept C512185932 @default.
• W2078668253 hasConcept C547475151 @default.
• W2078668253 hasConcept C552990157 @default.
• W2078668253 hasConcept C55493867 @default.
• W2078668253 hasConcept C67705224 @default.
• W2078668253 hasConcept C70883133 @default.
• W2078668253 hasConcept C73573662 @default.
• W2078668253 hasConcept C82381507 @default.
• W2078668253 hasConceptScore W2078668253C104317684 @default.
• W2078668253 hasConceptScore W2078668253C111921641 @default.
• W2078668253 hasConceptScore W2078668253C127716648 @default.
• W2078668253 hasConceptScore W2078668253C143065580 @default.
• W2078668253 hasConceptScore W2078668253C156719811 @default.
• W2078668253 hasConceptScore W2078668253C16318435 @default.
• W2078668253 hasConceptScore W2078668253C164965036 @default.
• W2078668253 hasConceptScore W2078668253C185592680 @default.
• W2078668253 hasConceptScore W2078668253C2756471 @default.
• W2078668253 hasConceptScore W2078668253C2776023528 @default.
• W2078668253 hasConceptScore W2078668253C2776639595 @default.
• W2078668253 hasConceptScore W2078668253C2776858809 @default.
• W2078668253 hasConceptScore W2078668253C512185932 @default.
• W2078668253 hasConceptScore W2078668253C547475151 @default.
• W2078668253 hasConceptScore W2078668253C552990157 @default.
• W2078668253 hasConceptScore W2078668253C55493867 @default.
• W2078668253 hasConceptScore W2078668253C67705224 @default.
• W2078668253 hasConceptScore W2078668253C70883133 @default.
• W2078668253 hasConceptScore W2078668253C73573662 @default.
• W2078668253 hasConceptScore W2078668253C82381507 @default.
• W2078668253 hasIssue "25" @default.
• W2078668253 hasLocation W20786682531 @default.
• W2078668253 hasLocation W20786682532 @default.
• W2078668253 hasOpenAccess W2078668253 @default.
• W2078668253 hasPrimaryLocation W20786682531 @default.
• W2078668253 hasRelatedWork W1511933811 @default.
• W2078668253 hasRelatedWork W1567770356 @default.
• W2078668253 hasRelatedWork W1974371829 @default.
• W2078668253 hasRelatedWork W2076035520 @default.
• W2078668253 hasRelatedWork W2078668253 @default.
• W2078668253 hasRelatedWork W2083202085 @default.
• W2078668253 hasRelatedWork W2112443661 @default.

• next