FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078668520> ?p ?o ?g. }

• W2078668520 endingPage "400" @default.
• W2078668520 startingPage "392" @default.
• W2078668520 abstract "Daidzein, a diphenolic isoflavone from many plants and herbs, has been reported to have anti-inflammatory properties. However, the effects of daidzein on lipopolysaccharide (LPS)-induced acute lung injury have not been determined. The aim of this study was to detect the effects of daidzein on LPS-induced acute lung injury and investigate the molecular mechanisms. Daidzein was intraperitoneally injected (2, 4, 8 mg/kg) 30 min after intratracheal instillation of LPS (5 mg/kg) in rats. The results showed that daidzein treatment remarkably improved the pulmonary histology and decreased the lung wet/dry weight ratios. We also found that daidzein significantly inhibited LPS-induced increases of macrophages and neutrophils infiltration of lung tissues, as well as markedly attenuated MPO activity. Moreover, daidzein effectively reduced the inflammatory cytokines release and total protein in bronchoalveolar lavage fluids (BALF). Furthermore, daidzein significantly inhibited LPS-induced toll-like receptor 4 (TLR4) and myeloid differentiation factor 88 (MyD88) protein up-expressions and NF-κB activation in lung tissues. In vitro, daidzein obviously inhibited the expressions of TLR4 and MyD88 and the activation of NF-κB in LPS-stimulated A549 alveolar epithelial cells. In conclusion, these data indicate that the anti-inflammatory effects of daidzein against LPS-induced ALI may be due to its ability to inhibit TLR4-MyD88-NF-κB pathway and daidzein may be a potential therapeutic agent for LPS-induced ALI." @default.
• W2078668520 created "2016-06-24" @default.
• W2078668520 creator A5001962625 @default.
• W2078668520 creator A5005500589 @default.
• W2078668520 creator A5013248335 @default.
• W2078668520 date "2015-06-01" @default.
• W2078668520 modified "2023-10-16" @default.
• W2078668520 title "Daidzein attenuates lipopolysaccharide-induced acute lung injury via toll-like receptor 4/NF-kappaB pathway" @default.
• W2078668520 cites W1511342801 @default.
• W2078668520 cites W1937357008 @default.
• W2078668520 cites W1951409959 @default.
• W2078668520 cites W1963762806 @default.
• W2078668520 cites W1965772617 @default.
• W2078668520 cites W1970225644 @default.
• W2078668520 cites W1974150753 @default.
• W2078668520 cites W1980611128 @default.
• W2078668520 cites W1982155022 @default.
• W2078668520 cites W1988273748 @default.
• W2078668520 cites W2003423901 @default.
• W2078668520 cites W2010453472 @default.
• W2078668520 cites W2024790024 @default.
• W2078668520 cites W2047290588 @default.
• W2078668520 cites W2049434285 @default.
• W2078668520 cites W2059957106 @default.
• W2078668520 cites W2064121269 @default.
• W2078668520 cites W2069317939 @default.
• W2078668520 cites W2071016611 @default.
• W2078668520 cites W2085206681 @default.
• W2078668520 cites W2088548720 @default.
• W2078668520 cites W2103735302 @default.
• W2078668520 cites W2116965731 @default.
• W2078668520 cites W2117047223 @default.
• W2078668520 cites W2123925631 @default.
• W2078668520 cites W2134887638 @default.
• W2078668520 cites W2150569822 @default.
• W2078668520 cites W2156613610 @default.
• W2078668520 cites W2157160136 @default.
• W2078668520 cites W2159763561 @default.
• W2078668520 cites W2335742033 @default.
• W2078668520 cites W2335925695 @default.
• W2078668520 cites W4233020934 @default.
• W2078668520 cites W4294658238 @default.
• W2078668520 doi "https://doi.org/10.1016/j.intimp.2015.04.002" @default.
• W2078668520 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25887269" @default.
• W2078668520 hasPublicationYear "2015" @default.
• W2078668520 type Work @default.
• W2078668520 sameAs 2078668520 @default.
• W2078668520 citedByCount "51" @default.
• W2078668520 countsByYear W20786685202015 @default.
• W2078668520 countsByYear W20786685202016 @default.
• W2078668520 countsByYear W20786685202017 @default.
• W2078668520 countsByYear W20786685202018 @default.
• W2078668520 countsByYear W20786685202019 @default.
• W2078668520 countsByYear W20786685202020 @default.
• W2078668520 countsByYear W20786685202021 @default.
• W2078668520 countsByYear W20786685202022 @default.
• W2078668520 countsByYear W20786685202023 @default.
• W2078668520 crossrefType "journal-article" @default.
• W2078668520 hasAuthorship W2078668520A5001962625 @default.
• W2078668520 hasAuthorship W2078668520A5005500589 @default.
• W2078668520 hasAuthorship W2078668520A5013248335 @default.
• W2078668520 hasConcept C126322002 @default.
• W2078668520 hasConcept C134018914 @default.
• W2078668520 hasConcept C170493617 @default.
• W2078668520 hasConcept C17991360 @default.
• W2078668520 hasConcept C185592680 @default.
• W2078668520 hasConcept C203014093 @default.
• W2078668520 hasConcept C2776070231 @default.
• W2078668520 hasConcept C2776914184 @default.
• W2078668520 hasConcept C2777714996 @default.
• W2078668520 hasConcept C2777730290 @default.
• W2078668520 hasConcept C2777961210 @default.
• W2078668520 hasConcept C2778298627 @default.
• W2078668520 hasConcept C2778754761 @default.
• W2078668520 hasConcept C2780955279 @default.
• W2078668520 hasConcept C55493867 @default.
• W2078668520 hasConcept C71924100 @default.
• W2078668520 hasConcept C98274493 @default.
• W2078668520 hasConceptScore W2078668520C126322002 @default.
• W2078668520 hasConceptScore W2078668520C134018914 @default.
• W2078668520 hasConceptScore W2078668520C170493617 @default.
• W2078668520 hasConceptScore W2078668520C17991360 @default.
• W2078668520 hasConceptScore W2078668520C185592680 @default.
• W2078668520 hasConceptScore W2078668520C203014093 @default.
• W2078668520 hasConceptScore W2078668520C2776070231 @default.
• W2078668520 hasConceptScore W2078668520C2776914184 @default.
• W2078668520 hasConceptScore W2078668520C2777714996 @default.
• W2078668520 hasConceptScore W2078668520C2777730290 @default.
• W2078668520 hasConceptScore W2078668520C2777961210 @default.
• W2078668520 hasConceptScore W2078668520C2778298627 @default.
• W2078668520 hasConceptScore W2078668520C2778754761 @default.
• W2078668520 hasConceptScore W2078668520C2780955279 @default.
• W2078668520 hasConceptScore W2078668520C55493867 @default.
• W2078668520 hasConceptScore W2078668520C71924100 @default.
• W2078668520 hasConceptScore W2078668520C98274493 @default.
• W2078668520 hasFunder F4320321001 @default.
• W2078668520 hasIssue "2" @default.
• W2078668520 hasLocation W20786685201 @default.

• next