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- W2078668524 abstract "Recently, Esch et al 1 Esch RE Bush RK Peden P Lockey RF Sublingual-oral administration of standardized allergenic extracts: phase 1 safety and dosing results. Ann Allergy Asthma Immunol. 2008; 100: 475-481 Abstract Full Text Full Text PDF PubMed Scopus (41) Google Scholar reported on a phase 1 safety and dosing trial for single allergen sublingual immunotherapy (SLIT). The authors note that a dose “up to more than 100 times the cumulative monthly doses currently used in subcutaneous immunotherapy (SCIT) is generally safe and without serious adverse effects.” They conclude this trial is the first step toward approval of home SLIT administration. Although this was a phase 1 trial, we think that important data were not presented. SUBLINGUAL-ORAL ADMINISTRATION OF STANDARDIZED ALLERGENIC EXTRACTS: PHASE 1 SAFETY AND DOSING RESULTSAnnals of Allergy, Asthma & ImmunologyVol. 101Issue 4PreviewThe maximum tolerable dose was initially estimated during the 1-day dose-escalation phase, and dose adjustments were made, if necessary, during the 8-week treatment course.1 In general, the patients were maintained on this maximum tolerable dose during the 8-week treatment course. Dose adjustments were made in 31 (35%) of the 88 patients, and there were no adverse events (AEs) among the 20 patients whose doses were increased. Full-Text PDF" @default.
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- W2078668524 date "2008-10-01" @default.
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- W2078668524 title "SUBLINGUAL-ORAL ADMINISTRATION OF STANDARDIZED ALLERGENIC EXTRACTS: PHASE 1 SAFETY AND DOSING RESULTS" @default.
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- W2078668524 doi "https://doi.org/10.1016/s1081-1206(10)60325-0" @default.
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