FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078672078> ?p ?o ?g. }

• W2078672078 endingPage "964" @default.
• W2078672078 startingPage "959" @default.
• W2078672078 abstract "Purpose To quantify cardiac radiation therapy (RT) exposure using sensitive measures of cardiac dysfunction; and to correlate dysfunction with heart doses, in the setting of adjuvant RT for left-sided breast cancer. Methods and Materials On a randomized trial, 32 women with node-positive left-sided breast cancer underwent pre-RT stress single photon emission computed tomography (SPECT-CT) myocardial perfusion scans. Patients received RT to the breast/chest wall and regional lymph nodes to doses of 50 to 52.2 Gy. Repeat SPECT-CT scans were performed 1 year after RT. Perfusion defects (PD), summed stress defects scores (SSS), and ejection fractions (EF) were evaluated. Doses to the heart and coronary arteries were quantified. Results The mean difference in pre- and post-RT PD was −0.38% ± 3.20% (P=.68), with no clinically significant defects. To assess for subclinical effects, PD were also examined using a 1.5-SD below the normal mean threshold, with a mean difference of 2.53% ± 12.57% (P=.38). The mean differences in SSS and EF before and after RT were 0.78% ± 2.50% (P=.08) and 1.75% ± 7.29% (P=.39), respectively. The average heart Dmean and D95 were 2.82 Gy (range, 1.11-6.06 Gy) and 0.90 Gy (range, 0.13-2.17 Gy), respectively. The average Dmean and D95 to the left anterior descending artery were 7.22 Gy (range, 2.58-18.05 Gy) and 3.22 Gy (range, 1.23-6.86 Gy), respectively. No correlations were found between cardiac doses and changes in PD, SSS, and EF. Conclusions Using sensitive measures of cardiac function, no clinically significant defects were found after RT, with the average heart Dmean <5 Gy. Although a dose response may exist for measures of cardiac dysfunction at higher doses, no correlation was found in the present study for low doses delivered to cardiac structures and perfusion, SSS, or EF. To quantify cardiac radiation therapy (RT) exposure using sensitive measures of cardiac dysfunction; and to correlate dysfunction with heart doses, in the setting of adjuvant RT for left-sided breast cancer. On a randomized trial, 32 women with node-positive left-sided breast cancer underwent pre-RT stress single photon emission computed tomography (SPECT-CT) myocardial perfusion scans. Patients received RT to the breast/chest wall and regional lymph nodes to doses of 50 to 52.2 Gy. Repeat SPECT-CT scans were performed 1 year after RT. Perfusion defects (PD), summed stress defects scores (SSS), and ejection fractions (EF) were evaluated. Doses to the heart and coronary arteries were quantified. The mean difference in pre- and post-RT PD was −0.38% ± 3.20% (P=.68), with no clinically significant defects. To assess for subclinical effects, PD were also examined using a 1.5-SD below the normal mean threshold, with a mean difference of 2.53% ± 12.57% (P=.38). The mean differences in SSS and EF before and after RT were 0.78% ± 2.50% (P=.08) and 1.75% ± 7.29% (P=.39), respectively. The average heart Dmean and D95 were 2.82 Gy (range, 1.11-6.06 Gy) and 0.90 Gy (range, 0.13-2.17 Gy), respectively. The average Dmean and D95 to the left anterior descending artery were 7.22 Gy (range, 2.58-18.05 Gy) and 3.22 Gy (range, 1.23-6.86 Gy), respectively. No correlations were found between cardiac doses and changes in PD, SSS, and EF. Using sensitive measures of cardiac function, no clinically significant defects were found after RT, with the average heart Dmean <5 Gy. Although a dose response may exist for measures of cardiac dysfunction at higher doses, no correlation was found in the present study for low doses delivered to cardiac structures and perfusion, SSS, or EF." @default.
• W2078672078 created "2016-06-24" @default.
• W2078672078 creator A5004113579 @default.
• W2078672078 creator A5009365214 @default.
• W2078672078 creator A5023290472 @default.
• W2078672078 creator A5026876827 @default.
• W2078672078 creator A5036507987 @default.
• W2078672078 creator A5036540537 @default.
• W2078672078 creator A5056073824 @default.
• W2078672078 creator A5074257091 @default.
• W2078672078 creator A5075661070 @default.
• W2078672078 creator A5076973801 @default.
• W2078672078 date "2013-03-01" @default.
• W2078672078 modified "2023-10-18" @default.
• W2078672078 title "Is There a Dose-Response Relationship for Heart Disease With Low-Dose Radiation Therapy?" @default.
• W2078672078 cites W1984502501 @default.
• W2078672078 cites W1987536026 @default.
• W2078672078 cites W2003997567 @default.
• W2078672078 cites W2024772261 @default.
• W2078672078 cites W2028663639 @default.
• W2078672078 cites W2044819115 @default.
• W2078672078 cites W2069393038 @default.
• W2078672078 cites W2078007296 @default.
• W2078672078 cites W2082280032 @default.
• W2078672078 cites W2083882781 @default.
• W2078672078 cites W2100025800 @default.
• W2078672078 cites W2109320466 @default.
• W2078672078 cites W2136621897 @default.
• W2078672078 cites W2140492419 @default.
• W2078672078 cites W2142397820 @default.
• W2078672078 cites W2149342403 @default.
• W2078672078 cites W2151585080 @default.
• W2078672078 cites W2154811939 @default.
• W2078672078 cites W2158615473 @default.
• W2078672078 doi "https://doi.org/10.1016/j.ijrobp.2012.08.002" @default.
• W2078672078 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5175458" @default.
• W2078672078 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23021709" @default.
• W2078672078 hasPublicationYear "2013" @default.
• W2078672078 type Work @default.
• W2078672078 sameAs 2078672078 @default.
• W2078672078 citedByCount "71" @default.
• W2078672078 countsByYear W20786720782012 @default.
• W2078672078 countsByYear W20786720782013 @default.
• W2078672078 countsByYear W20786720782014 @default.
• W2078672078 countsByYear W20786720782015 @default.
• W2078672078 countsByYear W20786720782016 @default.
• W2078672078 countsByYear W20786720782017 @default.
• W2078672078 countsByYear W20786720782018 @default.
• W2078672078 countsByYear W20786720782019 @default.
• W2078672078 countsByYear W20786720782020 @default.
• W2078672078 countsByYear W20786720782021 @default.
• W2078672078 countsByYear W20786720782022 @default.
• W2078672078 countsByYear W20786720782023 @default.
• W2078672078 crossrefType "journal-article" @default.
• W2078672078 hasAuthorship W2078672078A5004113579 @default.
• W2078672078 hasAuthorship W2078672078A5009365214 @default.
• W2078672078 hasAuthorship W2078672078A5023290472 @default.
• W2078672078 hasAuthorship W2078672078A5026876827 @default.
• W2078672078 hasAuthorship W2078672078A5036507987 @default.
• W2078672078 hasAuthorship W2078672078A5036540537 @default.
• W2078672078 hasAuthorship W2078672078A5056073824 @default.
• W2078672078 hasAuthorship W2078672078A5074257091 @default.
• W2078672078 hasAuthorship W2078672078A5075661070 @default.
• W2078672078 hasAuthorship W2078672078A5076973801 @default.
• W2078672078 hasBestOaLocation W20786720782 @default.
• W2078672078 hasConcept C113280763 @default.
• W2078672078 hasConcept C121608353 @default.
• W2078672078 hasConcept C126322002 @default.
• W2078672078 hasConcept C126838900 @default.
• W2078672078 hasConcept C146957229 @default.
• W2078672078 hasConcept C148699463 @default.
• W2078672078 hasConcept C164705383 @default.
• W2078672078 hasConcept C2778198053 @default.
• W2078672078 hasConcept C2778213512 @default.
• W2078672078 hasConcept C2780849966 @default.
• W2078672078 hasConcept C2989005 @default.
• W2078672078 hasConcept C509974204 @default.
• W2078672078 hasConcept C530470458 @default.
• W2078672078 hasConcept C71924100 @default.
• W2078672078 hasConcept C78085059 @default.
• W2078672078 hasConceptScore W2078672078C113280763 @default.
• W2078672078 hasConceptScore W2078672078C121608353 @default.
• W2078672078 hasConceptScore W2078672078C126322002 @default.
• W2078672078 hasConceptScore W2078672078C126838900 @default.
• W2078672078 hasConceptScore W2078672078C146957229 @default.
• W2078672078 hasConceptScore W2078672078C148699463 @default.
• W2078672078 hasConceptScore W2078672078C164705383 @default.
• W2078672078 hasConceptScore W2078672078C2778198053 @default.
• W2078672078 hasConceptScore W2078672078C2778213512 @default.
• W2078672078 hasConceptScore W2078672078C2780849966 @default.
• W2078672078 hasConceptScore W2078672078C2989005 @default.
• W2078672078 hasConceptScore W2078672078C509974204 @default.
• W2078672078 hasConceptScore W2078672078C530470458 @default.
• W2078672078 hasConceptScore W2078672078C71924100 @default.
• W2078672078 hasConceptScore W2078672078C78085059 @default.
• W2078672078 hasIssue "4" @default.
• W2078672078 hasLocation W20786720781 @default.
• W2078672078 hasLocation W20786720782 @default.

• next