Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078677462> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2078677462 endingPage "738" @default.
- W2078677462 startingPage "727" @default.
- W2078677462 abstract "The two sarcomeric actin genes, encoding alpha-cardiac and alpha-skeletal actins, are co-expressed in striated muscle, but in the adult the respective isoform predominates in cardiac or skeletal muscle of the normal mouse. We have investigated the interaction between this gene pair in different genetic contexts. Northern blot analysis of alpha-actin mRNA levels in different inbred mice (129/SJ, C3H, C57BL/6) demonstrates variation of as much as threefold in skeletal muscle and eightfold in cardiac muscle. High or low-level expression is seen for both skeletal and cardiac muscle in a given line, suggesting common regulatory phenomena affecting the abundant alpha-skeletal or alpha-cardiac transcript. In the BALB/c mouse, which has a mutant cardiac actin locus, skeletal as well as cardiac actin mRNA and protein accumulate in the adult heart. We have analysed the role of the two alpha-actin genes in this phenomenon in seven recombinant inbred mouse lines (BALB/c x C57BL/6) and in a cross (BALB/c x C3H). The results demonstrate that neither alpha-actin gene alone is sufficient, and implicate other regulatory loci. DNA sequencing of the C3H and BALB/c alpha-skeletal actin gene promoters shows that they are virtually identical over 830 nucleotides. The relative levels of alpha-skeletal and alpha-cardiac actin proteins have been measured by N-terminal peptide analysis in the different mouse lines. The results point to regulatory loci affecting mRNA utilization and protein stability." @default.
- W2078677462 created "2016-06-24" @default.
- W2078677462 creator A5037311694 @default.
- W2078677462 creator A5047318202 @default.
- W2078677462 creator A5049291299 @default.
- W2078677462 creator A5089747739 @default.
- W2078677462 date "1990-02-01" @default.
- W2078677462 modified "2023-10-12" @default.
- W2078677462 title "Genetic analysis of the interaction between cardiac and skeletal actin gene expression in striated muscle of the mouse" @default.
- W2078677462 cites W1536989691 @default.
- W2078677462 cites W1586288730 @default.
- W2078677462 cites W1681826624 @default.
- W2078677462 cites W1800027138 @default.
- W2078677462 cites W1817814372 @default.
- W2078677462 cites W1909145578 @default.
- W2078677462 cites W1936653461 @default.
- W2078677462 cites W1972101833 @default.
- W2078677462 cites W1974025350 @default.
- W2078677462 cites W1974608176 @default.
- W2078677462 cites W1980976884 @default.
- W2078677462 cites W2002279735 @default.
- W2078677462 cites W2050251634 @default.
- W2078677462 cites W2056097435 @default.
- W2078677462 cites W2058106399 @default.
- W2078677462 cites W2060333964 @default.
- W2078677462 cites W2064407772 @default.
- W2078677462 cites W2068341455 @default.
- W2078677462 cites W2075341263 @default.
- W2078677462 cites W2087229328 @default.
- W2078677462 cites W2090712867 @default.
- W2078677462 cites W2091842149 @default.
- W2078677462 cites W2102187053 @default.
- W2078677462 cites W2110720259 @default.
- W2078677462 cites W2135977869 @default.
- W2078677462 cites W2151355563 @default.
- W2078677462 cites W2284805631 @default.
- W2078677462 cites W2416501904 @default.
- W2078677462 cites W245433402 @default.
- W2078677462 cites W4231657009 @default.
- W2078677462 cites W4249611878 @default.
- W2078677462 doi "https://doi.org/10.1016/0022-2836(90)90073-u" @default.
- W2078677462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1690302" @default.
- W2078677462 hasPublicationYear "1990" @default.
- W2078677462 type Work @default.
- W2078677462 sameAs 2078677462 @default.
- W2078677462 citedByCount "32" @default.
- W2078677462 countsByYear W20786774622016 @default.
- W2078677462 countsByYear W20786774622020 @default.
- W2078677462 crossrefType "journal-article" @default.
- W2078677462 hasAuthorship W2078677462A5037311694 @default.
- W2078677462 hasAuthorship W2078677462A5047318202 @default.
- W2078677462 hasAuthorship W2078677462A5049291299 @default.
- W2078677462 hasAuthorship W2078677462A5089747739 @default.
- W2078677462 hasConcept C104317684 @default.
- W2078677462 hasConcept C125705527 @default.
- W2078677462 hasConcept C134018914 @default.
- W2078677462 hasConcept C150194340 @default.
- W2078677462 hasConcept C153911025 @default.
- W2078677462 hasConcept C177707886 @default.
- W2078677462 hasConcept C2778996579 @default.
- W2078677462 hasConcept C2779959927 @default.
- W2078677462 hasConcept C53345823 @default.
- W2078677462 hasConcept C54355233 @default.
- W2078677462 hasConcept C84597430 @default.
- W2078677462 hasConcept C86803240 @default.
- W2078677462 hasConceptScore W2078677462C104317684 @default.
- W2078677462 hasConceptScore W2078677462C125705527 @default.
- W2078677462 hasConceptScore W2078677462C134018914 @default.
- W2078677462 hasConceptScore W2078677462C150194340 @default.
- W2078677462 hasConceptScore W2078677462C153911025 @default.
- W2078677462 hasConceptScore W2078677462C177707886 @default.
- W2078677462 hasConceptScore W2078677462C2778996579 @default.
- W2078677462 hasConceptScore W2078677462C2779959927 @default.
- W2078677462 hasConceptScore W2078677462C53345823 @default.
- W2078677462 hasConceptScore W2078677462C54355233 @default.
- W2078677462 hasConceptScore W2078677462C84597430 @default.
- W2078677462 hasConceptScore W2078677462C86803240 @default.
- W2078677462 hasIssue "4" @default.
- W2078677462 hasLocation W20786774621 @default.
- W2078677462 hasLocation W20786774622 @default.
- W2078677462 hasOpenAccess W2078677462 @default.
- W2078677462 hasPrimaryLocation W20786774621 @default.
- W2078677462 hasRelatedWork W1886625688 @default.
- W2078677462 hasRelatedWork W2028087115 @default.
- W2078677462 hasRelatedWork W2033708131 @default.
- W2078677462 hasRelatedWork W2057739827 @default.
- W2078677462 hasRelatedWork W2074557265 @default.
- W2078677462 hasRelatedWork W2078677462 @default.
- W2078677462 hasRelatedWork W2082451158 @default.
- W2078677462 hasRelatedWork W2104498991 @default.
- W2078677462 hasRelatedWork W2954044368 @default.
- W2078677462 hasRelatedWork W2342237740 @default.
- W2078677462 hasVolume "211" @default.
- W2078677462 isParatext "false" @default.
- W2078677462 isRetracted "false" @default.
- W2078677462 magId "2078677462" @default.
- W2078677462 workType "article" @default.