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• W2078678198 abstract "The pharmacological profile of a new, safe, and effective hydrogen sulfide (H2S)-releasing derivative of aspirin (ACS14) is described. We report the synthesis of ACS14, and of its deacetylated metabolite (ACS21), the preliminary pharmacokinetics, and its in vivo metabolism, with the H2S plasma levels after intravenous administration in the rat. ACS14 maintains the thromboxane-suppressing activity of the parent compound, but seems to spare the gastric mucosa, by affecting redox imbalance through increased H2S/glutathione formation, heme oxygenase-1 promoter activity, and isoprostane suppression." @default.
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• W2078678198 date "2009-03-01" @default.
• W2078678198 modified "2023-10-11" @default.
• W2078678198 title "Pharmacological profile of a novel H2S-releasing aspirin" @default.
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• W2078678198 doi "https://doi.org/10.1016/j.freeradbiomed.2008.11.013" @default.
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