Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078678509> ?p ?o ?g. }
- W2078678509 endingPage "223" @default.
- W2078678509 startingPage "214" @default.
- W2078678509 abstract "In the last few years, SAXS of biological materials has been rapidly evolving and promises to move structural analysis to a new level. Recent innovations in SAXS data analysis allow ab initio shape predictions of proteins in solution. Furthermore, experimental scattering data can be compared to calculated scattering curves from the growing data base of solved structures and also identify aggregation and unfolded proteins. Combining SAXS results with atomic resolution structures enables detailed characterizations in solution of mass, radius, conformations, assembly, and shape changes associated with protein folding and functions. SAXS can efficiently reveal the spatial organization of protein domains, including domains missing from or disordered in known crystal structures, and establish cofactor or substrate-induced conformational changes. For flexible domains or unstructured regions that are not amenable for study by many other structural techniques, SAXS provides a unique technology. Here, we present SAXS shape predictions for PCNA that accurately predict a trimeric ring assembly and for a full-length DNA repair glycosylase with a large unstructured region. These new results in combination with illustrative published data show how SAXS combined with high resolution crystal structures efficiently establishes architectures, assemblies, conformations, and unstructured regions for proteins and protein complexes in solution." @default.
- W2078678509 created "2016-06-24" @default.
- W2078678509 creator A5042886731 @default.
- W2078678509 creator A5059713279 @default.
- W2078678509 creator A5068262437 @default.
- W2078678509 creator A5077551138 @default.
- W2078678509 creator A5079924550 @default.
- W2078678509 date "2007-05-01" @default.
- W2078678509 modified "2023-10-14" @default.
- W2078678509 title "Structural analysis of flexible proteins in solution by small angle X-ray scattering combined with crystallography" @default.
- W2078678509 cites W1974563774 @default.
- W2078678509 cites W1975121208 @default.
- W2078678509 cites W1977750999 @default.
- W2078678509 cites W1982126789 @default.
- W2078678509 cites W1984123187 @default.
- W2078678509 cites W1985447198 @default.
- W2078678509 cites W1986670774 @default.
- W2078678509 cites W1991357892 @default.
- W2078678509 cites W1999117143 @default.
- W2078678509 cites W2002246637 @default.
- W2078678509 cites W2005667072 @default.
- W2078678509 cites W2016874490 @default.
- W2078678509 cites W2021375991 @default.
- W2078678509 cites W2023129668 @default.
- W2078678509 cites W2023556453 @default.
- W2078678509 cites W2024793028 @default.
- W2078678509 cites W2030179515 @default.
- W2078678509 cites W2033552722 @default.
- W2078678509 cites W2050091361 @default.
- W2078678509 cites W2052606462 @default.
- W2078678509 cites W2054752802 @default.
- W2078678509 cites W2058206198 @default.
- W2078678509 cites W2072674961 @default.
- W2078678509 cites W2072927989 @default.
- W2078678509 cites W2072986569 @default.
- W2078678509 cites W2078245108 @default.
- W2078678509 cites W2084505555 @default.
- W2078678509 cites W2105021118 @default.
- W2078678509 cites W2116537286 @default.
- W2078678509 cites W2117925594 @default.
- W2078678509 cites W2119807590 @default.
- W2078678509 cites W2126856425 @default.
- W2078678509 cites W2134798467 @default.
- W2078678509 cites W2142017121 @default.
- W2078678509 cites W2147620484 @default.
- W2078678509 cites W2150022567 @default.
- W2078678509 cites W2163392206 @default.
- W2078678509 cites W2168909179 @default.
- W2078678509 cites W2170122994 @default.
- W2078678509 cites W2170408275 @default.
- W2078678509 cites W2624905707 @default.
- W2078678509 doi "https://doi.org/10.1016/j.jsb.2006.09.008" @default.
- W2078678509 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17182256" @default.
- W2078678509 hasPublicationYear "2007" @default.
- W2078678509 type Work @default.
- W2078678509 sameAs 2078678509 @default.
- W2078678509 citedByCount "64" @default.
- W2078678509 countsByYear W20786785092012 @default.
- W2078678509 countsByYear W20786785092013 @default.
- W2078678509 countsByYear W20786785092014 @default.
- W2078678509 countsByYear W20786785092015 @default.
- W2078678509 countsByYear W20786785092016 @default.
- W2078678509 countsByYear W20786785092017 @default.
- W2078678509 countsByYear W20786785092018 @default.
- W2078678509 countsByYear W20786785092019 @default.
- W2078678509 countsByYear W20786785092020 @default.
- W2078678509 countsByYear W20786785092021 @default.
- W2078678509 countsByYear W20786785092022 @default.
- W2078678509 countsByYear W20786785092023 @default.
- W2078678509 crossrefType "journal-article" @default.
- W2078678509 hasAuthorship W2078678509A5042886731 @default.
- W2078678509 hasAuthorship W2078678509A5059713279 @default.
- W2078678509 hasAuthorship W2078678509A5068262437 @default.
- W2078678509 hasAuthorship W2078678509A5077551138 @default.
- W2078678509 hasAuthorship W2078678509A5079924550 @default.
- W2078678509 hasBestOaLocation W20786785092 @default.
- W2078678509 hasConcept C120665830 @default.
- W2078678509 hasConcept C121332964 @default.
- W2078678509 hasConcept C131888329 @default.
- W2078678509 hasConcept C159467904 @default.
- W2078678509 hasConcept C178790620 @default.
- W2078678509 hasConcept C185592680 @default.
- W2078678509 hasConcept C191486275 @default.
- W2078678509 hasConcept C192562407 @default.
- W2078678509 hasConcept C2781442258 @default.
- W2078678509 hasConcept C8010536 @default.
- W2078678509 hasConceptScore W2078678509C120665830 @default.
- W2078678509 hasConceptScore W2078678509C121332964 @default.
- W2078678509 hasConceptScore W2078678509C131888329 @default.
- W2078678509 hasConceptScore W2078678509C159467904 @default.
- W2078678509 hasConceptScore W2078678509C178790620 @default.
- W2078678509 hasConceptScore W2078678509C185592680 @default.
- W2078678509 hasConceptScore W2078678509C191486275 @default.
- W2078678509 hasConceptScore W2078678509C192562407 @default.
- W2078678509 hasConceptScore W2078678509C2781442258 @default.
- W2078678509 hasConceptScore W2078678509C8010536 @default.
- W2078678509 hasIssue "2" @default.
- W2078678509 hasLocation W20786785091 @default.