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- W2078678809 endingPage "418" @default.
- W2078678809 startingPage "391" @default.
- W2078678809 abstract "Major depressive disorder (MDD) is characterized by structural and neurochemical changes in limbic structures, including the hippocampus, that regulate mood and cognitive functions. Hippocampal atrophy is observed in patients with depression and this effect is blocked or reversed by antidepressant treatments. Brain-derived neurotrophic factor and other neurotrophic/growth factors are decreased in postmortem hippocampal tissue from suicide victims, which suggests that altered trophic support could contribute to the pathophysiology of MDD. Preclinical studies demonstrate that exposure to stress leads to atrophy and cell loss in the hippocampus as well as decreased expression of neurotrophic/growth factors, and that antidepressant administration reverses or blocks the effects of stress. Accumulating evidence suggests that altered neurogenesis in the adult hippocampus mediates the action of antidepressants. Chronic antidepressant administration upregulates neurogenesis in the adult hippocampus and this cellular response is required for the effects of antidepressants in certain animal models of depression. Here, we review cellular (e.g. adult neurogenesis) and behavioral studies that support the neurotrophic/neurogenic hypothesis of depression and antidepressant action. Aberrant regulation of neuronal plasticity, including neurogenesis, in the hippocampus and other limbic nuclei may result in maladaptive changes in neural networks that underlie the pathophysiology of MDD." @default.
- W2078678809 created "2016-06-24" @default.
- W2078678809 creator A5056521587 @default.
- W2078678809 creator A5087594298 @default.
- W2078678809 date "2007-09-01" @default.
- W2078678809 modified "2023-10-09" @default.
- W2078678809 title "The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior" @default.
- W2078678809 cites W1483477190 @default.
- W2078678809 cites W1512847190 @default.
- W2078678809 cites W1518574168 @default.
- W2078678809 cites W1539896698 @default.
- W2078678809 cites W1593725384 @default.
- W2078678809 cites W1625103160 @default.
- W2078678809 cites W1647455825 @default.
- W2078678809 cites W1666500994 @default.
- W2078678809 cites W1710423957 @default.
- W2078678809 cites W1733539716 @default.
- W2078678809 cites W1775250759 @default.
- W2078678809 cites W1837633367 @default.
- W2078678809 cites W1864437270 @default.
- W2078678809 cites W1913938270 @default.
- W2078678809 cites W1914011667 @default.
- W2078678809 cites W1950744654 @default.
- W2078678809 cites W1963776543 @default.
- W2078678809 cites W1963940970 @default.
- W2078678809 cites W1965355495 @default.
- W2078678809 cites W1967017538 @default.
- W2078678809 cites W1967473656 @default.
- W2078678809 cites W1967490301 @default.
- W2078678809 cites W1968213313 @default.
- W2078678809 cites W1968483037 @default.
- W2078678809 cites W1969852349 @default.
- W2078678809 cites W1970945239 @default.
- W2078678809 cites W1971776075 @default.
- W2078678809 cites W1971954112 @default.
- W2078678809 cites W1972088939 @default.
- W2078678809 cites W1972764203 @default.
- W2078678809 cites W1973125755 @default.
- W2078678809 cites W1973386992 @default.
- W2078678809 cites W1973658683 @default.
- W2078678809 cites W1976136395 @default.
- W2078678809 cites W1977430165 @default.
- W2078678809 cites W1977550486 @default.
- W2078678809 cites W1978118406 @default.
- W2078678809 cites W1978526726 @default.
- W2078678809 cites W1979742071 @default.
- W2078678809 cites W1980166225 @default.
- W2078678809 cites W1981116212 @default.
- W2078678809 cites W1981724466 @default.
- W2078678809 cites W1981957263 @default.
- W2078678809 cites W1983620892 @default.
- W2078678809 cites W1983660540 @default.
- W2078678809 cites W1983706324 @default.
- W2078678809 cites W1984253712 @default.
- W2078678809 cites W1984460802 @default.
- W2078678809 cites W1985237413 @default.
- W2078678809 cites W1985616298 @default.
- W2078678809 cites W1985991621 @default.
- W2078678809 cites W1986560360 @default.
- W2078678809 cites W1986618663 @default.
- W2078678809 cites W1987432599 @default.
- W2078678809 cites W1987604172 @default.
- W2078678809 cites W1987850841 @default.
- W2078678809 cites W1987972424 @default.
- W2078678809 cites W1988157885 @default.
- W2078678809 cites W1989060739 @default.
- W2078678809 cites W1989378157 @default.
- W2078678809 cites W1989385052 @default.
- W2078678809 cites W1990806594 @default.
- W2078678809 cites W1993636230 @default.
- W2078678809 cites W1993911530 @default.
- W2078678809 cites W1995556701 @default.
- W2078678809 cites W1996567906 @default.
- W2078678809 cites W1996925219 @default.
- W2078678809 cites W1998711535 @default.
- W2078678809 cites W1998786335 @default.
- W2078678809 cites W1998934862 @default.
- W2078678809 cites W1999476423 @default.
- W2078678809 cites W1999871144 @default.
- W2078678809 cites W2000273941 @default.
- W2078678809 cites W2000292756 @default.
- W2078678809 cites W2000793737 @default.
- W2078678809 cites W2001736388 @default.
- W2078678809 cites W2001743962 @default.
- W2078678809 cites W2002050752 @default.
- W2078678809 cites W2002700392 @default.
- W2078678809 cites W2003180479 @default.
- W2078678809 cites W2003547326 @default.
- W2078678809 cites W2004118951 @default.
- W2078678809 cites W2004240294 @default.
- W2078678809 cites W2004286315 @default.
- W2078678809 cites W2005594217 @default.
- W2078678809 cites W2005690269 @default.
- W2078678809 cites W2006119116 @default.
- W2078678809 cites W2007869908 @default.
- W2078678809 cites W2008566143 @default.
- W2078678809 cites W2008671190 @default.
- W2078678809 cites W2008719521 @default.