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• W2078684185 abstract "Attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) along with UV-Vis was used to distinguish between structural differences between a normal human breast cell line (MCF-12 F) and a cancerous breast cell line (MCF-7) after both being treated with conjugated gold nanoparticles and unconjugated gold nanoparticles. The MCF-7 cell line possessed a small amount of epidermal growth factor receptors (EGFR) on its cell surface whereas the MCF-12 F cell line did not. The anti-EGFR antibodies blocked the binding of epidermal growth factors to this receptor which plays an important role in the regulation of cell growth, proliferation, and differentiation. The infrared (IR) spectra for both cell lines yield several differences between normal biological samples and cancerous samples. As the malignancy of the sample increases, the peak intensity and wavenumber positions decrease. The same conclusion was drawn from thin-layers of conjugated nanoparticles and nonconjugated nanoparticles. The p..." @default.
• W2078684185 created "2016-06-24" @default.
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• W2078684185 date "2013-01-01" @default.
• W2078684185 modified "2023-10-05" @default.
• W2078684185 title "Differentiation Between Anti-Epidermal Growth Factor Receptors Antibody Conjugated and Unconjugated Gold Nanoparticles Using Attenuated Total Reflectance–Fourier Transform Infrared Spectroscopy" @default.
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• W2078684185 doi "https://doi.org/10.1080/00032719.2012.706846" @default.
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