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• W2078685035 abstract "Staphylococcus aureus is a common cause of hospital-acquired diseases, with some diseases as a result of infection of medical devices such as artificial heart valves, catheters and orthopedic implants. Multidrug resistance is commonly observed in hospital isolates of methicillin-resistant S. aureus (MRSA), which are characterized by a mobile chromosomal element (SCCmec) encoding a penicillin binding protein (PBP) known as PBP2A. Because of its low affinity for β-lactam antibiotics, PBP2a allows cell–wall synthesis at β-lactam concentrations that inhibit other PBPs. For this reason, the glycopeptides antibiotics vancomycin and teicoplanin are frequently used to treat multiresistant MRSA infections. It was anticipated that intensive use of these antibiotics would eventually promote emergence of resistant clones, severely limiting therapeutic options [ 1 Tenover F.C. Moellering Jr., R.C. The rationale for revising the Clinical and Laboratory Standards Institute vancomycin minimal inhibitory concentration interpretive criteria for Staphylococcus aureus. Clin. Infect. Dis. 2007; 44: 1208-1215 Crossref PubMed Scopus (370) Google Scholar ]. Interestingly, it took almost 50 years before the first truly vancomycin-resistant clinical isolates were described that carried the vanA resistance gene cassette (VRSA), presumably transmitted from Enterococcus[ 1 Tenover F.C. Moellering Jr., R.C. The rationale for revising the Clinical and Laboratory Standards Institute vancomycin minimal inhibitory concentration interpretive criteria for Staphylococcus aureus. Clin. Infect. Dis. 2007; 44: 1208-1215 Crossref PubMed Scopus (370) Google Scholar ]. In contrast, an intermediate or low-level resistance, ascribed to innate vancomycin resistance in the absence of vanA, arises both in vivo and in vitro in S. aureus following prolonged drug exposure [ 1 Tenover F.C. Moellering Jr., R.C. The rationale for revising the Clinical and Laboratory Standards Institute vancomycin minimal inhibitory concentration interpretive criteria for Staphylococcus aureus. Clin. Infect. Dis. 2007; 44: 1208-1215 Crossref PubMed Scopus (370) Google Scholar , 2 Hiramatsu K. Vancomycin-resistant Staphylococcus aureus: a new model of antibiotic resistance. Lancet Infect. Dis. 2001; 1: 147-155 Abstract Full Text Full Text PDF PubMed Scopus (599) Google Scholar ]. Strains that exhibit vancomycin intermediate resistance (VISA) and glycopeptide intermediate resistance (GISA, referring to both teicoplanin and vancomycin), as well as those displaying intermediate resistance to only teicoplanin, have been described." @default.
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• W2078685035 date "2010-02-01" @default.
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• W2078685035 title "Exploring innate glycopeptide resistance mechanisms in Staphylococcus aureus" @default.
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• W2078685035 doi "https://doi.org/10.1016/j.tim.2009.11.005" @default.
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