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- W2078685065 endingPage "539" @default.
- W2078685065 startingPage "527" @default.
- W2078685065 abstract "Argatroban is a synthetic, small-molecule direct thrombin inhibitor that is approved in the USA, the EU and Japan for prophylaxis or treatment of thrombosis in patients with heparin-induced thrombocytopenia (HIT), and for anticoagulation of HIT patients undergoing PCI. Argatroban binds reversibly to, and inhibits both soluble and clot-bound thrombin. Argatroban does not generate antibodies, is not susceptible to degradation by proteases and is cleared hepatically. It has a predictable anticoagulant effect and there is a good correlation between dose, plasma concentration and pharmacodynamic effect. Initial clinical studies suggest that further investigations to establish the use of argatroban in ischemic stroke, acute coronary syndrome, hemodialysis, blood oxygenation, off-pump cardiac surgery and other clinical indications are warranted." @default.
- W2078685065 created "2016-06-24" @default.
- W2078685065 creator A5007859032 @default.
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- W2078685065 creator A5055893524 @default.
- W2078685065 creator A5064983817 @default.
- W2078685065 creator A5074304553 @default.
- W2078685065 date "2010-10-01" @default.
- W2078685065 modified "2023-09-26" @default.
- W2078685065 title "Pharmacology of argatroban" @default.
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- W2078685065 doi "https://doi.org/10.1586/ehm.10.53" @default.
- W2078685065 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21083469" @default.
- W2078685065 hasPublicationYear "2010" @default.