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• W2078689375 abstract "We report DNA and predicted protein sequence similarities, implying homology, among genes of double-stranded DNA (dsDNA) bacteriophages and prophages spanning a broad phylogenetic range of host bacteria. The sequence matches reported here establish genetic connections, not always direct, among the lambdoid phages of Escherichia coli , phage φC31 of Streptomyces , phages of Mycobacterium , a previously unrecognized cryptic prophage, φflu, in the Haemophilus influenzae genome, and two small prophage-like elements, φRv1 and φRv2, in the genome of Mycobacterium tuberculosis . The results imply that these phage genes, and very possibly all of the dsDNA tailed phages, share common ancestry. We propose a model for the genetic structure and dynamics of the global phage population in which all dsDNA phage genomes are mosaics with access, by horizontal exchange, to a large common genetic pool but in which access to the gene pool is not uniform for all phage." @default.
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• W2078689375 date "1999-03-02" @default.
• W2078689375 modified "2023-10-16" @default.
• W2078689375 title "Evolutionary relationships among diverse bacteriophages and prophages: All the world’s a phage" @default.
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• W2078689375 doi "https://doi.org/10.1073/pnas.96.5.2192" @default.
• W2078689375 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/26759" @default.
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