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- W2078690832 abstract "KW-5805, 5-[2-(diethylamino)ethyl]amino-5,11-dihydro[1]benzoxepino [3,4-b] pyridine trihydrochloride, is a new tricyclic compound with antiulcer activities. Its effect on stimulated gastric acid secretion was investigated in the perfused stomach of anesthetized rats. KW-5805 at 0.3–10 mg/kg, i.v., dose-dependently inhibited gastric acid secretion stimulated by 2-deoxy-D-glucose (2-DG). On the other hand, the compound at 10-20 mg/kg, i.v., exerted a moderate decrease in gastric acid secretion stimulated by bethanechol; and at 10 mg/kg, i.v., it produced no change in gastric acid secretion evoked peripherally by vagal electrical stimulation. When applied intracerebroventricularly at 1–5 μg/rat, this compound dose-relatedly reduced gastric acid secretion stimulated by 2-DG. Three main metabolites (KF-10504, KF-9530 and KF-10847) of KW-5805 at 1 mg/kg, i.v., caused no significant decrease in gastric acid secretion stimulated by 2-DG. Doxepin, a tricyclic compound, definitely depressed the 2-DG stimulated gastric acid secretion at 1 mg/kg, i.v. It is suggested that intravenous administration of KW-5805 inhibits gastric acid secretion stimulated by 2-DG, mainly via centrally mediated mechanisms, and that biotransformation of KW-5805 to the metabolites contributes little to the development of the antisecretory effect." @default.
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- W2078690832 date "1990-01-01" @default.
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- W2078690832 title "Centrally mediated inhibitory effect of 5-(2-(diethylamino)ethyl)amino-5,11-dihydro(1)benzoxepino(3,4-b)pyridine trihydrochloride (KW-5805) on gastric acid secretion in rats." @default.
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- W2078690832 doi "https://doi.org/10.1254/jjp.52.287" @default.
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