Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078693458> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2078693458 endingPage "325" @default.
- W2078693458 startingPage "319" @default.
- W2078693458 abstract "The seizure threshold for different seizure components was measured after slow intravenous infusion of bicuculline in the rat. Clear differences were seen in the seizure threshold for tremor (TRE) and clonic-forepaw (CLOF) as compared to clonic-hindpaw (CLOH) and tonic-forepaw (TONF). Seizure threshold was measured after treatment with different doses of diazepam, pentobarbital, D-etomidate, picrotoxin, RO15-1788 and (+/-)-5-(1,3,-dimethylbutyl)-5-barbituric acid (DMBB). Direct and indirect antagonism between the agonists and antagonists was examined. The interactions between the drugs for TRE and CLOF resemble those described in in vitro receptor-binding assays using the GABA-benzodiazepine-chloride ionophore complex (GBCI). The interactions for CLOH and TONF do not show this resemblance, suggesting less involvement of GABA in these phenomena. Diazepam was selectively antagonized by RO15-1788. D-Etomidate and pentobarbital were directly antagonized by DMBB, suggesting shared activity at the barbiturate site. No evidence was found for an interaction between compounds acting at different sites within the GBCI." @default.
- W2078693458 created "2016-06-24" @default.
- W2078693458 creator A5005166405 @default.
- W2078693458 date "1983-10-01" @default.
- W2078693458 modified "2023-10-17" @default.
- W2078693458 title "Diazepam, pentobarbital and d-etomidate produced increases in bicuculline seizure threshold; Selective antagonism by RO15-1788, picrotoxin and (±)-DMBB" @default.
- W2078693458 cites W1964325563 @default.
- W2078693458 cites W1965666249 @default.
- W2078693458 cites W1983404085 @default.
- W2078693458 cites W1985055774 @default.
- W2078693458 cites W1987437619 @default.
- W2078693458 cites W1992456051 @default.
- W2078693458 cites W2007911341 @default.
- W2078693458 cites W2011950043 @default.
- W2078693458 cites W2013926783 @default.
- W2078693458 cites W2014987337 @default.
- W2078693458 cites W2017363078 @default.
- W2078693458 cites W2032372670 @default.
- W2078693458 cites W2056945518 @default.
- W2078693458 cites W2066628109 @default.
- W2078693458 cites W2067565788 @default.
- W2078693458 cites W2086100228 @default.
- W2078693458 cites W2093993020 @default.
- W2078693458 cites W2095513664 @default.
- W2078693458 cites W2470813274 @default.
- W2078693458 cites W53049737 @default.
- W2078693458 doi "https://doi.org/10.1016/0014-2999(83)90421-1" @default.
- W2078693458 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6317405" @default.
- W2078693458 hasPublicationYear "1983" @default.
- W2078693458 type Work @default.
- W2078693458 sameAs 2078693458 @default.
- W2078693458 citedByCount "23" @default.
- W2078693458 countsByYear W20786934582014 @default.
- W2078693458 countsByYear W20786934582020 @default.
- W2078693458 crossrefType "journal-article" @default.
- W2078693458 hasAuthorship W2078693458A5005166405 @default.
- W2078693458 hasConcept C15744967 @default.
- W2078693458 hasConcept C168258287 @default.
- W2078693458 hasConcept C169760540 @default.
- W2078693458 hasConcept C170493617 @default.
- W2078693458 hasConcept C185592680 @default.
- W2078693458 hasConcept C2775858608 @default.
- W2078693458 hasConcept C2776175493 @default.
- W2078693458 hasConcept C2776277131 @default.
- W2078693458 hasConcept C2776755955 @default.
- W2078693458 hasConcept C2777383412 @default.
- W2078693458 hasConcept C2778186239 @default.
- W2078693458 hasConcept C2778460930 @default.
- W2078693458 hasConcept C2779324764 @default.
- W2078693458 hasConcept C2779676917 @default.
- W2078693458 hasConcept C2780077838 @default.
- W2078693458 hasConcept C2780763569 @default.
- W2078693458 hasConcept C42219234 @default.
- W2078693458 hasConcept C55493867 @default.
- W2078693458 hasConcept C71924100 @default.
- W2078693458 hasConcept C98274493 @default.
- W2078693458 hasConceptScore W2078693458C15744967 @default.
- W2078693458 hasConceptScore W2078693458C168258287 @default.
- W2078693458 hasConceptScore W2078693458C169760540 @default.
- W2078693458 hasConceptScore W2078693458C170493617 @default.
- W2078693458 hasConceptScore W2078693458C185592680 @default.
- W2078693458 hasConceptScore W2078693458C2775858608 @default.
- W2078693458 hasConceptScore W2078693458C2776175493 @default.
- W2078693458 hasConceptScore W2078693458C2776277131 @default.
- W2078693458 hasConceptScore W2078693458C2776755955 @default.
- W2078693458 hasConceptScore W2078693458C2777383412 @default.
- W2078693458 hasConceptScore W2078693458C2778186239 @default.
- W2078693458 hasConceptScore W2078693458C2778460930 @default.
- W2078693458 hasConceptScore W2078693458C2779324764 @default.
- W2078693458 hasConceptScore W2078693458C2779676917 @default.
- W2078693458 hasConceptScore W2078693458C2780077838 @default.
- W2078693458 hasConceptScore W2078693458C2780763569 @default.
- W2078693458 hasConceptScore W2078693458C42219234 @default.
- W2078693458 hasConceptScore W2078693458C55493867 @default.
- W2078693458 hasConceptScore W2078693458C71924100 @default.
- W2078693458 hasConceptScore W2078693458C98274493 @default.
- W2078693458 hasIssue "3-4" @default.
- W2078693458 hasLocation W20786934581 @default.
- W2078693458 hasLocation W20786934582 @default.
- W2078693458 hasOpenAccess W2078693458 @default.
- W2078693458 hasPrimaryLocation W20786934581 @default.
- W2078693458 hasRelatedWork W1965612245 @default.
- W2078693458 hasRelatedWork W1976130361 @default.
- W2078693458 hasRelatedWork W1993333230 @default.
- W2078693458 hasRelatedWork W2035255650 @default.
- W2078693458 hasRelatedWork W2045867284 @default.
- W2078693458 hasRelatedWork W2053318736 @default.
- W2078693458 hasRelatedWork W2073541800 @default.
- W2078693458 hasRelatedWork W2074354560 @default.
- W2078693458 hasRelatedWork W2078693458 @default.
- W2078693458 hasRelatedWork W2094256528 @default.
- W2078693458 hasVolume "94" @default.
- W2078693458 isParatext "false" @default.
- W2078693458 isRetracted "false" @default.
- W2078693458 magId "2078693458" @default.
- W2078693458 workType "article" @default.